表观遗传学:它是关于什么的?

E. Saade, V. Ogryzko
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引用次数: 3

摘要

在过去的几十年里,表观遗传学引起了科学家们的注意,但它的范围一直在不断变化。在本文中,我们概述了其定义是如何以及为什么演变的,并建议对该领域中使用的概念进行澄清,特别是表观遗传信息,表观遗传稳定性和表观遗传模板的概念。我们要解决的另一个问题是表观遗传信息的作用。它不仅在允许遗传信息的替代解释方面很重要,而且在保护遗传信息方面也很重要,此外,我们认为这种功能首先出现在进化中,后来才招募表观遗传机制在细胞分化中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetics: What it is about?
Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in this field, in particular, on the notions of epigenetic information, epigenetic stability and epigenetic templating. Another issue that we address is the role of epigenetic information. Not only it is important in allowing alternative interpretations of genetic information, but it appears to be important in protecting the genetic information, moreover, we suggest that this function appeared first in evolution and only later on the epigenetic mechanisms were recruited to play a role in cell differentiation.
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