C Caruso, M A Modica, G Candore, C Di Giulio, A Galluzzo, C Giordano, P Di Marco, V Gebbia, M Tamone Reyes, P Citarrella
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Soluble interleukin-2 receptor in vitro production by mononuclear cells from Hodgkin patients.
Lymphocytes of patients with Hodgkin's disease have a deficient production of Interleukin-2. Recently, a soluble form of the receptor for IL-2 has been demonstrated in human sera and in vitro-stimulated culture supernatants from human T lymphocytes. In the present paper we report the production of soluble IL-2R from peripheral blood mononuclear cells in H.D. The unstimulated MNC of patients released more sIL-2R than controls. No difference was observed between PHA-stimulated MNC of patients and controls. These preliminary findings suggest that soluble IL-2R may be provide a new tool for the study of immunological dysregulation in H.D.
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