【直肠癌放疗的适应症】。

Radiobiologia, radiotherapia Pub Date : 1990-01-01
R Winkler, H D Franke, A Dörner
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引用次数: 0

摘要

在直肠癌的局部控制中,手术与放疗互为补充。对肿瘤的放射治疗效果往往是确定的。辅助放疗是最有趣的指征,尽管目前也是最具争议的。通过对所有数据的分析和自身辐照研究的经验,我们毫不怀疑,如果治疗的首要目的是防止最常见和最常见的治疗失败形式的局部复发,则该适应症适用于联合治疗。在这个问题中,自由基照射形式,如前照射、累积照射(三明治技术)和后照射,都优于单独的前照射。本研究的结果是,我们进行了25 Gy的预照射,随后立即进行手术,并在已证实的高风险阶段(T大于或等于3nomo,Tx N1-3 Mo)累积照射至50 Gy。如果肿瘤侵袭到邻近地区导致原发性局部不治之症,则进行50 Gy的预照射,并在4-6周内进行探查性腹腔镜手术。近60%的肿瘤可以手术治疗。同样,我们也治疗未接受放射治疗的局部肿瘤复发患者。对于一般或全身无法治愈的患者,需要造口的患者,我们会进行经肛门肿瘤缩小手术,然后进行50 Gy的放射治疗。特别是这一治疗原则在80岁以上的病人身上得到了证明。在这里,可以接受的生存质量和避免造口,生存可以达到与这个生命阶段的统计生存相对应的生存。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Indications for radiotherapy of rectal cancer].

Surgery and radiotherapy complete each other in local control of suffering from rectal carcinoma. A radiotherapeutic effect on tumor is secured often. The adjuvant radiotherapy is the most interesting indication, though the most controversial as present too. Analysing all data and with experiences of an own irradiation study we have not any doubt that the indication is qualified for a combined therapy, if the therapeutic aim with priority is to prevent a local relapse as the most frequent and complained of form of therapeutic failure. In this problem, radical irradiation forms, as pre- and accumulating irradiation (sandwich-technique) and after-irradiation, render superior to an exclusive pre irradiation. In result of this study we practise a preirradiation of 25 Gy with immediately following operation and an accumulating irradiation to 50 Gy in proved high-risk-stage (T greater than or equal to 3 NoMo,Tx N1-3 Mo). If there is a primary local incurability by tumor invasion into the neighbourhood a pre-irradiation is done with 50 Gy and following explorative laparatomy within 4-6 weeks. Nearly 60% of these tumors become operable after that. Likewise we practise in unirradiated patients with locoregional tumor recurrence. Also here the extirpation quota of patients with general or systemic incurability, that a stoma construction is required in, we carry out a transanal tumor reduction and irradiate with 50 Gy after that. Especially this therapeutic principle has proved its worth in patients that are past eighty. Here with acceptable living quality and avoiding a stoma construction a survival can be reached that corresponds to the statistical survival of this stage of life.

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