健康成人的巨噬细胞暴露于鼠源卡氏肺囊虫后释放tnf - α。初步研究。

Medicina (Florence, Italy) Pub Date : 1990-10-01

E Tamburrini, A De Luca, G Ventura, G Maiuro, A Siracusano, E Ortona, A Antinori

{"title":"健康成人的巨噬细胞暴露于鼠源卡氏肺囊虫后释放tnf - α。初步研究。","authors":"E Tamburrini, A De Luca, G Ventura, G Maiuro, A Siracusano, E Ortona, A Antinori","doi":"","DOIUrl":null,"url":null,"abstract":"The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.","PeriodicalId":77570,"journal":{"name":"Medicina (Florence, Italy)","volume":"10 4","pages":"393-4"},"PeriodicalIF":0.0000,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Macrophages from healthy adults release TNF-alpha after exposure to Pneumocystis carinii of murine origin. Preliminary study].\",\"authors\":\"E Tamburrini, A De Luca, G Ventura, G Maiuro, A Siracusano, E Ortona, A Antinori\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.\",\"PeriodicalId\":77570,\"journal\":{\"name\":\"Medicina (Florence, Italy)\",\"volume\":\"10 4\",\"pages\":\"393-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina (Florence, Italy)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina (Florence, Italy)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

研究了卡氏肺囊虫诱导健康成人巨噬细胞释放tnf - α的能力。单核细胞和单核细胞衍生的巨噬细胞暴露于从类固醇诱导肺囊虫病大鼠获得的卡氏假包囊时产生大量的tnf - α。tnf - α释放具有卡氏假单胞菌特异性，这是由抗卡氏假单胞菌抑制的结果。Carinii高免疫血清，它不是由假定的内毒素痕迹介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Macrophages from healthy adults release TNF-alpha after exposure to Pneumocystis carinii of murine origin. Preliminary study].

The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Medicina (Florence, Italy)

自引率

0.00%

发文量