Reporting on Adverse Clinical Events

A 70-year-old male patient developed worsening pain and swelling of the left breast of 1 month duration. Medications at the time of medical evaluation included bicalutamide (50 mg daily for 12 months), atorvastatin (20 mg daily), allopurinol, acetylsalicylic acid, and tamsulosin. No vitamins or herbal supplements were noted on the medication history. A physical examination revealed a tender enlarged left breast without bleeding or discharge. Imaging studies indicated an enlarged left breast with normal glandular tissues and vascularity. Laboratory values were within normal limits. Treatment included the substitution of ezetimibe (10 mg daily) for atorvastatin, resulting in symptomatic improvement by 3 months without recurrence. The authors concluded that this patient developed atorvastatin-related gynecomastia based on the temporal relationship between the administration of the drug and the appearance and resolution of symptoms. According to the Naranjo causality scale, this relationship between the drug and causality was classified as probable. Atorvastatin [Atorvastatin] Famularo G et al (Giuseppe Famularo: San Camillo Hospital, Rome, Italy; e-mail: None provided) Atorvastatin-associated gynecomastia. Ann Pharmacotherapy 55(10):1300–1301 (Oct) 2021