Coagulation and fibrinolysis in rats after confinement hypokinesia.

Our previous experiments (14) (15) dealt with the dynamic of the fluid-coagulant equilibrium in rats after exposure to confinement hypokinesia (CHK) at different time intervals, 1, 3, 7, 21, 28 and 35 days. We found a decreased Quiq and Howell time (QT and HT) in some relation with the time of exposure, with a tendency to normalization after 21 days. The same evolution was shown by the number of thrombocytes and of the euglobulin lysis time (ELT). In this work we prolonged the exposure to CHK for 60 days, an interval after which a series of other functional parameters significantly approached initial control values (16). We found an important approach to normal values also with the QT, HT, Elt and with the number of thrombocytes. Concomitantly, the plasma concentration of corticosterone (the principal glucocorticoid of rats), that increased over shorter intervals, approached also control values after 60 days of exposure to CHK. Nevertheless, it can not explain the changes of coagulability, because it decreases after adrenalectomy but the QT, HT and thrombocytes are already decreased. For these and other reasons it results that the relation of adrenal hormones to coagulation needs be further clarified.