伴及不伴循环系统病变的系统性红斑狼疮问题的现代认识(文献回顾,临床病例描述)(第一次通报)

L. Kobak, O. Abrahamovych, U. Abrahamovych, V. Chemes
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引用次数: 1

摘要

上下文。系统性红斑狼疮(SLE)的患病率和发病率在世界范围内是显著的。近年来,SLE的患病率有上升的趋势。尽管对SLE的病因、发病机制、诊断和治疗的认识取得了不容置疑的进展,但患者(包括年轻人和工作年龄的患者)的死亡率高于一般人群,而循环系统病变是这些病例的主要原因之一。目标。分析文献,致力于对系统性红斑狼疮伴或不伴循环系统病变问题的现代观点,描述临床病例。材料和方法。运用内容分析法、系统与比较分析法、文献语义学方法研究SLE现代诊治原则的科学调查现状。本文描述了一个临床病例。结果。本文就本病的病因病机提出现代观点。SLE的临床表现非常多样。病变的合并症和共向性问题是相关的。SLE时心血管系统的病变可表现为心包炎、心肌炎、心内膜炎,心瓣膜、冠状动脉、主动脉、传导系统的病变,肺动脉高压的发生。药物治疗的基本原则也被简要地考虑。结论。文献综述的结果表明了系统性红斑狼疮问题的重要性,因为它在年轻人和工作年龄人群中广泛流行,缺乏对疾病的病因和发病机制的准确认识,许多器官和系统的共病病变,包括循环系统,发展为严重的,往往危及生命的表现。缺乏明确的建议来预测药物的差异化使用,并考虑到合并症的syntropic病变,这在所描述的临床病例中也得到了证明。因此,系统性红斑狼疮需要进一步深入研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modern View on the Problem of Systemic Lupus Erythematosus with and without Comorbid Lesions of the Circulatory System (Literature Review, Clinical Case Description) (first notice)
Context. The prevalence and incidence of systemic lupus erythematosus (SLE) in the world is significant. In recent years, there has been a tendency of the SLE prevalence increase. despite the undoubted progress in understanding the etiology and pathogenesis of SLE, its diagnosis and treatment, the mortality of patients, including ones at young and working age, is higher than in the general population, and circulatory system lesions are ones of its main reasons in these cases. Objective. To analyze the literature, dedicated to the modern view on the problem of systemic lupus erythematosus with and without comorbid lesions of the circulatory system, describe the clinical case. Materials and methods. Content analysis, method of system and comparative analysis, bibliosemantic method of studying the current scientific investigations on modern principles of diagnosis and treatment of patients with SLE are used. A clinical case is described. Results. The article presents modern ideas about the etiological factors and pathogenesis of the disease. The clinical manifestations of SLE are very diverse. The problem of comorbidity and syntropy of lesions is relevant. Lesions of the cardiovascular system in the case of SLE can manifest itself in the form of pericarditis, myocarditis, endocarditis, lesions of the heart valves, coronary arteries, aorta, conduction system, pulmonary hypertension occurrence. The basic principles of drug therapy are also briefly considered. Conclusions. The results of the literature review indicate the importance of the problem of systemic lupus erythematosus, due to its widespread prevalence among the young and people of working age, lack of accurate knowledge about the etiology and pathogenesis of the disease, comorbid lesions of many organs and systems, including circulatory system, the development of severe and often life-threatening manifestations, the lack of clear recommendations that would predict the differentiated use of drugs taking into account comorbid syntropic lesions, which is also demonstrated in the described clinical case. Given this, systemic lupus erythematosus needs further in-depth study.
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