3,4-二氨基吡啶磷酸对SOD1-G93A症状小鼠的影响

Swathi Beladakere Ramaswamy, J. Stanford, S. Iyadurai, R. Govindarajan, R. Barohn
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摘要

目的:研究3,4-磷酸二氨基吡啶(3,4- dapp)对SOD1-G93A症状小鼠体重、握力、神经系统评分及生存的影响。方法:从90日龄开始,以0、8、16 mg/kg的剂量给SOD1-G93A小鼠3,4-二氨基吡啶磷酸(3,4- dapp) 5天/周。我们测量了这个ALS模型的体重、握力、神经学评分和生存率。结果:3,4- dapp对小鼠体重、握力、神经学评分及存活均无影响。结论:我们的研究表明,3,4- dapp给药对SOD1突变小鼠的生存、体重、握力和神经学评分没有影响。由于本研究的结果意义有限,需要更大规模的动物研究来调查3,4- dapp的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of 3,4-diaminopyridine phosphate in symptomatic SOD1-G93A mice
Objective: To study the effect of 3,4-diaminopyridine phosphate (3,4-DAPP) on body weight, grip strength, neurological score and survival in symptomatic SOD1-G93A mice.   Method: We administered 3,4-diaminopyridine phosphate (3,4-DAPP) at 0, 8, and 16 mg/kg to SOD1-G93A mice 5 days/week beginning at 90 days of age. We measured body weight, grip strength, neurological score and survival in this model of ALS.   Results: 3,4-DAPP had no influence on body weight, grip strength, neurological score or survival in this transgenic mouse model.   Conclusion: Our study showed that 3,4-DAPP administration had no effects on survival, body weight, grip strength and neurological score of mice with SOD1 mutation. Since the results of this study are of limited significance, larger animal studies are required to investigate the utility of 3,4-DAPP.
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