{"title":"[半抗原携带模式物质的结构对接触反应的影响:DNCB致敏后α -丙氨酸立体异构体的DNP共轭物]。","authors":"G Schwartze, D Lübbe","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>By means of epicutaneous tests under standard conditions we studied the cell-mediated contact sensitivity to dinitrophenyl (DNP) conjugates of the stereoisomeric amino acids L-alpha-alanine and D-alpha-alanine, respectively, in patients sensitized with dinitrochlorobenzene (DNCB). There was no difference in the number of positive skin responses with the two enantiomeric compounds DNP-L-alpha-alanine (16/26) and DNP-D-alpha-alanine (17/26). However, as in earlier studies, no patient has shown a positive reaction to the position-isomeric DNP-beta-alanine.</p>","PeriodicalId":11046,"journal":{"name":"Dermatologische Monatschrift","volume":"176 10","pages":"609-13"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of structure of hapten carrying model substances on contact reaction: DNP conjugates of stereoisomers of alpha-alanine following DNCB sensitization].\",\"authors\":\"G Schwartze, D Lübbe\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>By means of epicutaneous tests under standard conditions we studied the cell-mediated contact sensitivity to dinitrophenyl (DNP) conjugates of the stereoisomeric amino acids L-alpha-alanine and D-alpha-alanine, respectively, in patients sensitized with dinitrochlorobenzene (DNCB). There was no difference in the number of positive skin responses with the two enantiomeric compounds DNP-L-alpha-alanine (16/26) and DNP-D-alpha-alanine (17/26). However, as in earlier studies, no patient has shown a positive reaction to the position-isomeric DNP-beta-alanine.</p>\",\"PeriodicalId\":11046,\"journal\":{\"name\":\"Dermatologische Monatschrift\",\"volume\":\"176 10\",\"pages\":\"609-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatologische Monatschrift\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologische Monatschrift","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
通过标准条件下的表皮试验，我们研究了二硝基氯苯(DNCB)致敏患者对立体异构体氨基酸l- α -丙氨酸和d - α -丙氨酸的二硝基苯基(DNP)偶联物细胞介导的接触敏感性。两种对映体化合物dnp - l - α -丙氨酸(16/26)和dnp - d - α -丙氨酸(17/26)在皮肤阳性反应的数量上没有差异。然而，在早期的研究中，没有患者对位置异构体dnp - β -丙氨酸表现出积极的反应。
[Effect of structure of hapten carrying model substances on contact reaction: DNP conjugates of stereoisomers of alpha-alanine following DNCB sensitization].
By means of epicutaneous tests under standard conditions we studied the cell-mediated contact sensitivity to dinitrophenyl (DNP) conjugates of the stereoisomeric amino acids L-alpha-alanine and D-alpha-alanine, respectively, in patients sensitized with dinitrochlorobenzene (DNCB). There was no difference in the number of positive skin responses with the two enantiomeric compounds DNP-L-alpha-alanine (16/26) and DNP-D-alpha-alanine (17/26). However, as in earlier studies, no patient has shown a positive reaction to the position-isomeric DNP-beta-alanine.
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