热成像技术评估疼痛的可行性研究

R. Morello, A. Sagaidachnyi, D. Quattrone
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引用次数: 1

摘要

疼痛是一种使人衰弱的疾病,影响着世界上大约20%的成年人。它可以看作是人体对有害状态发出警报的一种预警机制或反应。它涉及复杂的神经元过程,被认为是一种带有相关主观成分的个人体验。在特定的情况下,疼痛会使人虚弱到改变感觉和态度。所以疼痛对身体,心理和社会都有重要影响它会影响生活质量。如果没有适当和及时的治疗,免疫系统可能会受到损害,痛觉可能会干扰人的进食、集中注意力、睡眠或与他人互动的能力。因此,及时和准确的疼痛评估是必不可少的加快治疗管理。今天,慢性疼痛的评估、管理和治疗仍然是研究人员和临床医生的挑战目标。神经科医生在缺乏标准的客观检测工具的情况下进行疼痛评估。由于疼痛仍然局限于一种主观体验,它就像评估疼痛的黄金标准一样,有患者的自我报告。因此,很明显需要定义新的客观评估工具。在本文中,作者建议使用主动热成像来分析神经源性炎症反应,这是痛觉性疼痛的特征。现报告这项可行性研究的初步结果。结果表明,热成像的潜力是一个筛选的生物标志物机制负责交感神经系统异常,由于疼痛。事实上,在几个案例中,疼痛受试者的热反应明显异常。已经观察到四肢温度分布的不对称性,在特定情况下,甚至突出了外部热刺激的温度调节反应的不平衡趋势。虽然,这些温度差异并没有在所有受试者中以相同的强度和频率观察到,但数据提供了使用热成像分析疼痛机制的潜力的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility Study of Pain Assessment by using Thermography
Pain is a debilitating condition affecting about 20% of adults in the world. It can be considered as a warning mechanism or the response of human body to alert about a harmful state. It involves complex neuronal processes and it is considered as a personal experience with a relevant subjective component. In specific conditions, pain can be so debilitating that it alters feelings and attitudes. So pain has important physical, psychological and social consequences and it can affect the quality of life. In absence of suitable and prompt treatments, the immune system can be compromised and pain sensation can interfere with the person ability to eat, concentrate, sleep, or interact with others. Consequently, the prompt and accurate pain assessment is essential for expediting therapeutic administration. Today, assessment, management and treatment of chronic pain are still challenging goals for researchers and clinicians. Algologists operate in absence of standard objective detection tools for pain assessment. As it remains confined to a subjective experience, pain has, like gold standard for its assessment, the patients' self-report. So it is clear the need to define new objective assessing tools. In this paper, the authors propose the use of the active thermography to analyse the neurogenic inflammatory response which characterizes nociceptive pain. Preliminary results of this feasibility study are here reported. Results have shown the potentiality of thermography to be a screening biomarker of the mechanism responsible of the abnormalities in sympathetic nervous system due to pain. In fact, a clear abnormality in the thermal response of subjects suffering from pain has been recorded in several cases. Asymmetries in temperature distribution of the two limbs have been observed, and in specific cases, an unbalanced trend of the thermoregulatory response to external thermal stimuli has been even highlighted. Although, these temperature differences have not been observed in all subjects with the same intensity and frequency, data provide evidence on the potentiality about the use of thermography to analyse pain mechanism.
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