A.Tanju Özçelikay , Orhan Altinkurt , Yusuf Öztürk , Nuray Yildizoǧlu-Ari , V.Melih Altan
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Biostatistical modeling of the effect of intravenous histamine-infusion on the rat gastric acid secretion
In this study, a variety of linear and nonlinear biostatistical models of regression were tested to evaluate the histamine-induced gastric acid secretion using the lumen-perfusion model in the rat. Among the linear, parabolic, and polynomial models tested, 3rd- and 4th-order polynomial models of regression exerted best correlations between the time and histamine-induced gastric acid secretion. In order to avoid undulatory behaviors in the regression curves, we conducted the polynomial regression analysis up to 5th order.
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