talin自身抑制的解除触发了与血管蛋白的力无关的关联

The Journal of Cell Biology Pub Date : 2019-12-05 DOI:10.1083/jcb.201903134

P. Atherton, Franziska Lausecker, Alexandre F. Carisey, A. Gilmore, D. Critchley, I. Barsukov, C. Ballestrem

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引用次数: 40

摘要

Talin和vinculin通过连接粘附受体到可收缩的肌动蛋白细胞骨架来控制机械传感。Atherton等人利用线粒体靶向系统阐明了调节血管蛋白与talin结合所需构象变化的机制。这两种蛋白与粘附调节蛋白paxillin相互作用都不需要这种激活机制。

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Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin binding to talin. Such activation mechanisms are not required for either protein to interact with the adhesion regulatory protein paxillin.

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The Journal of Cell Biology

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