微白蛋白尿与肥胖和超重妇女的内皮功能障碍无关,但与空腹血糖密切相关

Rômulo Bagano Menezes, R. Sampaio, A. Guimarães, L. Olivieri, M. L. Lima, A. Ladeia
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引用次数: 0

摘要

本研究旨在评估超重和肥胖妇女内皮功能障碍与微量白蛋白尿水平之间的关系。方法:本横断面研究分析BMI≥25 Kg/ m2的微量白蛋白尿患者的次要资料,并将其进行内皮功能检查并插入调查数据库。通过反应性充血试验(内皮依赖性血管舒张)评估内皮功能。结果:纳入41例女性,年龄53 ~±11岁,BMI 32.56±5.06 Kg/ m2, WC 100.36±23.21 cm。微量白蛋白尿与内皮功能无相关性。多因素logistic回归分析发现空腹血糖(β = 0.804;p < 0,00,1)和HDL (β = - 0.309;P = 0.048)水平作为微量白蛋白尿的独立预测因子。结论:微量白蛋白尿不能作为亚临床动脉粥样硬化的标志,但可以与空腹血糖和HDL水平相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MICROALBUMINURIA IS NOT ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN OBESE AND OVERWEIGHT WOMEN, BUT IS STRONGLY CORRELATED WITH FASTING GLYCEMIA
This study aimed to evaluate the association between endothelial dysfunction and microalbuminuria levels in overweight and obese women. Methods: This cross-sectional study analyzed secondary data of patients with BMI ≥ 25 Kg/m 2 who had microalbuminuria and endothelial function test already performed and inserted into the survey database. The endothelial function was evaluated by reactive hyperemia test (endothelium-dependent vasodilation). Results: This study included 41 women aged of 53 ­ ± 11 years, BMI of 32.56 ± 5.06 Kg/m 2 , WC  of 100.36 ± 23.21 cm. There was no correlation between microalbuminuria and endothelial function. A multivariate logistic regression analysis identified   glucose fasting (β = 0.804; p < 0,00,1) and HDL (β = - 0.309; p = 0.048) levels  as independent predictors of microalbuminuria. Conclusion: Microalbuminuria is not useful as a marker of subclinical atherosclerosis in this population, however can be associated to glucose fasting and HDL levels.
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