SUBACCUTE TOXICITY YELLOW FLOWER EXTRACT (Cananga odorata) ON HISTOPATHOLOGY OF WHITE RAT HEART (Rattus norvegicus)

Background: The inflammatory process is influenced by chemical mediators such as nitric oxide (NO), cytokines, and arachidonic acid metabolites. Currently, herbal treatment techniques are preferred by the public because they generally do not cause side effects. The therapeutic effect of herbal plants comes from the content of phytochemicals that have strong antioxidant activity. Objective of the study was to examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methodology: this research is a two-stage research, namely in vitro and in vivo tests. Many previous studies have proven that anti-inflammatory activity is not only related to antioxidant activity but also its ability to suppress the production of nitric oxide and pro-inflammatory cytokines. This effect is still being developed using a variety of herbal plants. One of the plants whose effects have not been studied in the field of health-medicine is ylang flower. Cananga odorata (Annonaceae) or ylang flower plant is a tropical plant that has fragrant petals and thrives without requiring special care. Results of the study were total phenol 1,06 %w/w and antioxidant IC50 DPPH by spectrophotometric examination was 808.86 ppm. These results do not show good antioxidant activity of ylang flower extract. Research in rats showed a decrease in blood glucose levels but not in lipid profiles. Furthermore, the toxicity test did not show any toxicity in experimental rats. Histological appearances showed no differences in cardiovascular disease model mice with standard-feeding mice. Conclusions: Cananga odorata ethanol extract did not showed any toxicity on histopatology on white rat heart.