包被微纳米投影贴片的靶向表皮递送疫苗

2008 International Conference on Nanoscience and Nanotechnology Pub Date : 2008-10-07 DOI:10.1109/ICONN.2008.4639262

T. Prow, Xianfeng Chen, M. Crichton, Y. Tiwari, F. Gradassi, K. Raphelli, D. Mahony, G. Fernando, M. Roberts, M. Kendall

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引用次数: 3

摘要

经皮接种疫苗有可能大大提高免疫的有效性和安全性。这项工作表征了我们的新型微纳米针及其在体外和体内的有效载荷释放谱。我们发现这些干涂层的微纳米针可以快速地将有效载荷传递到表皮。

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Targeted epidermal delivery of vaccines from coated micro-nanoprojection patches

Transcutaneous vaccine delivery has the potential to greatly improve immunization effectiveness and safety. This work characterizes our novel micro-nanoneedles and their payload release profile in vitro and in vivo. We found that these dry-coated micro-nanoneedles quickly deliver the payload to the epidermis.

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2008 International Conference on Nanoscience and Nanotechnology

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