DADNP: Dual Antibacterial Drug-Nanoparticle Systems Machine learning Approach

Abstract. The rise of new infectious diseases, combined with an increase in antibiotic resistance among bacterial pathogens, poses a significant health danger to humans. This ever-increasing threat of bacterial resistance necessitates the development of novel techniques to overcome this barrier. One of the successful strategies for combating antibiotic resistance has been the conjugation of nanoparticles (NPs) with antimicrobial moieties such as antibiotics, peptides, or other biomolecules. However, Dual Antibacterial Drug-Nanoparticle (DADNP) discovery is a slow