{"title":"人类移植物抗宿主病","authors":"R Parkman","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The principal clinical problem encountered following allogeneic bone marrow transplantation is acute and chronic graft-versus-host disease. The presence of acute graft-versus-host disease is the strongest predictor for the development of chronic graft-versus-host disease. The introduction of new prophylactic regimens has reduced the incidence of acute graft-versus-host disease. The clinical presentation and pathophysiology of acute and chronic graft-versus-host disease are discussed. New therapies for chronic graft-versus-host disease may result in improved treatment for human autoimmune diseases.</p>","PeriodicalId":77170,"journal":{"name":"Immunodeficiency reviews","volume":"2 4","pages":"253-64"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human graft-versus-host disease.\",\"authors\":\"R Parkman\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The principal clinical problem encountered following allogeneic bone marrow transplantation is acute and chronic graft-versus-host disease. The presence of acute graft-versus-host disease is the strongest predictor for the development of chronic graft-versus-host disease. The introduction of new prophylactic regimens has reduced the incidence of acute graft-versus-host disease. The clinical presentation and pathophysiology of acute and chronic graft-versus-host disease are discussed. New therapies for chronic graft-versus-host disease may result in improved treatment for human autoimmune diseases.</p>\",\"PeriodicalId\":77170,\"journal\":{\"name\":\"Immunodeficiency reviews\",\"volume\":\"2 4\",\"pages\":\"253-64\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunodeficiency reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunodeficiency reviews","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The principal clinical problem encountered following allogeneic bone marrow transplantation is acute and chronic graft-versus-host disease. The presence of acute graft-versus-host disease is the strongest predictor for the development of chronic graft-versus-host disease. The introduction of new prophylactic regimens has reduced the incidence of acute graft-versus-host disease. The clinical presentation and pathophysiology of acute and chronic graft-versus-host disease are discussed. New therapies for chronic graft-versus-host disease may result in improved treatment for human autoimmune diseases.
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