设计了一种用于控制胰岛素泵的药物驱动系统,并采用两点校准算法实现了单片机的硬件实现

A. Paglinawan, C. Paglinawan, Johneil T. Javier, Adrian O. Paa, Julius Austin Lim B. So, Euneale A. Tiu, Wen-Yaw Chung
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引用次数: 2

摘要

该研究涵盖了一种药物驱动系统,该系统可用于连续血糖监测系统,旨在驱动泵来管理胰岛素,以对抗糖尿病。该系统从一个微控制器单元开始,该单元具有模拟电压输入,该输入来自于相对于葡萄糖浓度的校准线性曲线,微控制器算法处理数据并确定是否需要输出胰岛素或胰高血糖素。微控制器单元的输出是一个时变脉冲,它依赖于葡萄糖浓度读数。另外,为了使系统能够植入,对实际的药物驱动电路进行了完整的定制IC设计。对单片机的硬件测试表明,该算法可以正确读取葡萄糖浓度并提供相应的输出。然而,微控制器中存在影响输出响应的延迟。对于药物驱动电路的完全定制IC设计,观察到寄生电容和电阻影响电路的传播延迟和功耗,但仍然可以用于药物驱动系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A design of a drug driver system for controlling an insulin pump and microcontroller hardware implementation using two-point calibration algorithm
The study covered a drug driver system that can be used for continuous glucose monitoring system intended to drive a pump that will administer insulin for the purpose of combating diabetes. The system begins with a microcontroller unit having an analog voltage input that is derived from a calibrated linearity curve relative to that of glucose concentration, the microcontroller algorithm processes the data and determines whether an output of insulin or glucagon is needed. The output of the microcontroller unit is a time variable pulse which is dependent on the glucose concentration reading. Separately, a full custom IC design is conducted for an actual drug driver circuit for the purpose of miniaturization to make the system viable for implantation. The hardware test for the microcontroller unit indicates that the algorithm can be used to properly read glucose concentrations and provide an output accordingly. However, there are delays within the microcontroller which affect the response of the output. For the full custom IC design of the drug driver circuit, it is observed that the parasitic capacitances and resistances affect the propagation delay and power dissipation of the circuit but can still be used in a drug driver system.
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