{"title":"随着年龄的增长，人类大脑中基因表达的变化","authors":"Lilach Soreq","doi":"10.47363/jnrrr/2022(5)169","DOIUrl":null,"url":null,"abstract":"Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.","PeriodicalId":309719,"journal":{"name":"Journal of Neurology Research Reviews & Reports","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gene Expression Changes in the Human Brain Upon Aging\",\"authors\":\"Lilach Soreq\",\"doi\":\"10.47363/jnrrr/2022(5)169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.\",\"PeriodicalId\":309719,\"journal\":{\"name\":\"Journal of Neurology Research Reviews & Reports\",\"volume\":\"46 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurology Research Reviews & Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47363/jnrrr/2022(5)169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology Research Reviews & Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jnrrr/2022(5)169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gene Expression Changes in the Human Brain Upon Aging
Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.
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