随着年龄的增长,人类大脑中基因表达的变化

Lilach Soreq
{"title":"随着年龄的增长,人类大脑中基因表达的变化","authors":"Lilach Soreq","doi":"10.47363/jnrrr/2022(5)169","DOIUrl":null,"url":null,"abstract":"Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.","PeriodicalId":309719,"journal":{"name":"Journal of Neurology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gene Expression Changes in the Human Brain Upon Aging\",\"authors\":\"Lilach Soreq\",\"doi\":\"10.47363/jnrrr/2022(5)169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.\",\"PeriodicalId\":309719,\"journal\":{\"name\":\"Journal of Neurology Research Reviews & Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurology Research Reviews & Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47363/jnrrr/2022(5)169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology Research Reviews & Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jnrrr/2022(5)169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

衰老是包括人类在内的所有生物的普遍现象。迄今为止,很少有研究关注衰老过程中人类大脑中RNA表达的变化。特别是,我分析了神经元和神经胶质细胞类型标记基因的差异表达基于外显子微阵列数据从总体1234个死后个体大脑样本(16岁至100岁以上)和10个大脑区域。我还使用高分辨率成像和机器学习分析来量化神经元和少突胶质细胞。我的研究对人类大脑衰老过程中细胞类型特异性基因表达的变化有了深入的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene Expression Changes in the Human Brain Upon Aging
Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信