体外循环去除实验性诱导犬肌肾病代谢综合征的血清肌红蛋白。

H Takasaki, T Hadama, R Matsushima, S Watanabe, J Shirabe
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引用次数: 1

摘要

用甲基丙烯酸甲酯-二乙烯基苯(MMA-DVB)填充柱体外循环去除狗实验性肌肾病代谢综合征的血清肌红蛋白。所有动物在动脉血流恢复后5小时后肢均出现明显水肿,内收肌变性或坏死。无体外循环组(1组)血液再灌注后血清肌红蛋白、肌酸酐磷酸激酶、谷草转氨酶和醛缩酶水平呈线性升高。5例中有4例肾小管中有大量肌红蛋白铸型沉积物,几乎所有小管的肾上皮中都有免疫反应性肌红蛋白。采用MMA-DVB柱体外循环再灌注组,血清肌红蛋白被柱选择性吸附,在0.5、1、2和3 h时明显低于1组。同时,近曲小管肾上皮中缺乏或缺乏免疫反应性肌红蛋白。因此,本研究表明,体外循环使用MMA-DVB柱可用于从实验诱导的肌肾病代谢综合征中去除血清肌红蛋白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracorporeal circulation for the removal of serum myoglobin in experimentally induced myonephropathic metabolic syndrome in dogs.

The removal of serum myoglobin with extracorporeal circulation using a column filled with methylmethacrylate-divinylbenzene (MMA-DVB) was studied in experimentally induced myonephropathic metabolic syndrome in the dog. All animals showed marked edema in the hind limbs and degeneration or necrosis of the adductor muscle 5 hours after the reestablishment of arterial flow. The serum levels of myoglobin, creatinine phosphokinase, glutamic oxaloacetic transaminase and aldolase increased linearly after the reperfusion of blood in the group of animals which received no extracorporeal circulation (group 1). Sediments of numerous myoglobin casts in the renal tubules and immunoreactive myoglobin in the renal epithelium of almost all the tubules were seen in 4 out of 5 cases. In the group of animals reperfused with extracorporeal circulation using the MMA-DVB column, serum myoglobin was adsorbed selectively by the column and showed a significantly lower value at 0.5, 1, 2 and 3 hours than that of the group 1 animals. Concomitantly, the immunoreactive myoglobin was absent or scant in the renal epithelium of the proximal convoluted tubule. The present study therefore indicates that extracorporeal circulation using the MMA-DVB column is useful for the removal of serum myoglobin from experimentally induced myonephropathic metabolic syndrome.

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