系统性红斑狼疮抗c反应蛋白抗体研究进展

P. Richter, A. Burlui, I. Bratoiu, A. Cardoneanu, C. Rezus, E. Rezus
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引用次数: 1

摘要

系统性红斑狼疮(SLE)是一种原型自身免疫性疾病,其特点是产生过多的自身抗体,在疾病相关组织损伤的发展中起着各种作用。c反应蛋白(CRP)是一种具有五聚体结构的急性相反应物。在酸性或碱性条件下,或当尿素水平高和/或钙水平低时,五聚体(pCRP)不可逆地解离成单体CRP (mCRP)并暴露新的表位(neo-CRP)。重要的是,抗mcrp(而非抗pcrp)抗体已在SLE患者中发现,其患病率在不同队列中从4%到78%不等。大量研究调查了针对CRP (anti-CRP)的自身抗体与疾病活动性之间的关系,以及它们与狼疮性肾炎(LN)的关系,经常报道不同的结果。本综述的主要目的是根据目前可用的数据描述抗mcrp抗体在SLE中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus
Abstract Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage. C-reactive protein (CRP) is an acute phase reactant with a pentameric structure. Under acidic or alkaline conditions, or when urea levels are high and/or calcium levels are low, the pentamer (pCRP) dissociates irreversibly into monomeric CRP (mCRP) and exposes new epitopes (neo-CRP). Importantly, anti-mCRP (but not anti-pCRP) antibodies have been described in patients with SLE, their prevalence varying from 4% to 78% in different cohorts. Numerous studies have investigated the relationship between autoantibodies directed against CRP (anti-CRP) and disease activity as well as their association with lupus nephritis (LN), frequently reporting discrepant findings. The main objective of the present review is to describe the role of anti-mCRP antibodies in SLE according to the currently available data.
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