在球周阻滞中加入维拉帕米局部麻醉剂用于玻璃体视网膜手术术中麻醉和术后镇痛的效果:一项随机临床试验

Iman S. Aboul Fetouh, Rehab S Khattab, A. Salem, N. Naguib, Tamer Omar
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引用次数: 0

摘要

目的评价维拉帕米辅助局麻二氯卡因和布比卡因用于玻璃体视网膜手术中球周阻滞的疗效和安全性。背景和设计本盲法、随机对照试验在埃及眼科研究所进行。患者与方法将82例符合条件的患者随机分为两组。对照组给予木卡因、布比卡因、生理盐水治疗。维拉帕米组治疗方法与对照组相同,但用维拉帕米5 mg代替生理盐水。主要结局包括感觉阻滞、运动阻滞、眼睑运动障碍、阻滞持续时间和患者血流动力学。次要结局包括术后疼痛、首次镇痛时间、患者和外科医生的满意度。结果维拉帕米组感觉阻滞发生时间明显短于对照组(分别为42.6±10.1 s和52.2±23.6 s);P = 0.020)。维拉帕米组VAS评分平均等级在2 h时较对照组显著下降(分别为30.72比47.50;P = 0.001)。另外,运动阻滞和眼睑运动障碍的中位数和平均阻滞时间在两组间无显著差异。结论维拉帕米5 mg加入2%木卡因5 ml和0.5%布比卡因5 ml的混合物中用于球周阻滞可显著缩短感觉阻滞的发生时间,减轻术后疼痛,但不影响运动阻滞的发生时间和麻醉时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of adding verapamil to local anesthetics in peribulbar block for intraoperative anesthesia and postoperative analgesia in vitreoretinal surgery: a randomized clinical trial
Aims To evaluate the efficacy and safety of verapamil as an adjuvant to the local anesthetics xylocaine and bupivacaine for peribulbar block in vitreoretinal surgery. Settings and design This blinded, randomized, controlled trial was carried out at the Research Institute of Ophthalmology, Egypt. Patients and methods A total of 82 eligible patients were randomly allocated into two groups. The control group received xylocaine, bupivacaine, and normal saline. Verapamil group were treated the same way as the control group but received 5 mg of verapamil instead of normal saline. The primary outcomes included the onset of sensory block, motor block, lid akinesia, duration of the block, and patients’ hemodynamics. Secondary outcomes included postoperative pain, time to first analgesia, and patient’s and surgeon’s satisfaction. Results The onset of sensory block was significantly shorter in the verapamil group compared with the control group (42.6±10.1 vs. 52.2±23.6 s, respectively; P=0.020). A significant decrease in the mean rank of VAS score was recorded at two h in the verapamil group compared with the control group (30.72 vs. 47.50, respectively; P=0.001). Otherwise, the medians of motor block and lid akinesia and the mean duration of block did not show significant differences between the two groups. Conclusions Addition of 5 mg of verapamil to a mixture of 5 ml of xylocaine 2% and 5 ml of bupivacaine 0.5% in peribulbar block significantly shortened the onset of sensory block and reduced the postoperative pain but did not affect the onset of motor block or the duration of anesthesia.
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