{"title":"可膨胀笼在脊柱转移中的应用","authors":"Shiveindra B. Jeyamohan, A. Vaccaro, J. Harrop","doi":"10.29046/jhnj.004.4.002","DOIUrl":null,"url":null,"abstract":"Introduction: Expandable cages have been utilized as an option for immediate spinal stabilization after vertebrectomy. However, long-term follow-up in the oncology population has not been studied, and results remain unclear. This single-institution series of patients represents our success in utilizing expandable cages. Methods: A retrospective chart review for patients with spinal metastasis treated with expandable cages between 2001 and 2006 was performed with IRB approval. Data regarding date of anterior and posterior surgery, immediate postoperative neurological status versus preoperative status, revision, equipment status, pseudoarthrosis, time to ambulation, and mortality were gathered and analyzed. Results: Twenty-four patients with metastatic cancer to the spine were studied. Cages were placed from T5-L5, 21 of which were single level. Of the 24 patients, 5 (21%) were neurologically intact pre-operatively and postoperatively. 13 of the 24 (54%) improved postoperatively. The remaining six (25%) illustrated no change in neurologic status. No patients deteriorated. At two years’ follow-up, overall patient survival was 79%. Average time to ambulation for patients followed was 11.5 days. No revisions were done for hardware failure, while one revision was performed for tumor progression. Conclusions: Expandable cages appear to be a valid treatment option for the immediate stabilization of the spine following corpectomy from spinal metastasis. Results indicate that fast recovery, reasonable long-term mortality, and immediate stabilization are achievable with this modality. Consequently, expandable cages should be considered as a valid option in the treatment for stabilization following corpectomy in metastasis to the spine. Introduction The spinal column is a frequent site of metastatic disease, particularly from lung, prostate, breast, kidney as the primary sources, whereas primary spinal column tumors comprise a minority of spinal pathology (<2%) 4. Although patients may present in a variety of conditions, pathologic fractures or increased axial spinal pain are frequent issues. Surgical treatment for this disease includes decompression of the neural elements, alleviation of painful symptoms, resolution of mechanical instabilization, and resection of the oncologic burden 2. Surgical treatment options for patients with progressive neurologic deterioration include anterior, posterior or combined decompression with subsequent spinal reconstructions. Expandable cages have recently been utilized as a treatment option for spinal reconstruction after vertebrectomy, particularly in the trauma population1. With increased familiarity of these devices, cages are now being utilized after corpectomy from tumor metastasis, but data regarding this treatment option is lacking 2-3. Vertebral body replacement with expandable cages may provide several potential theoretical advantages such as permitting optimal anatomic placement in addition to concurrent correction of spinal deformity. This manuscript consists of a retrospective review of clinical data from expandable cages after corpectomy in spinal metastatic disease. The hypothesis was these devices would be well tolerated and thus a treatment option in this difficult patient population. Clinical Materials and Methods Between June 2001 and November 2006, twenty-four consecutive patients were retrospectively identified through a chart review that underwent expandable cage reconstruction for metastatic disease with pathologic fractures. Patient research protocol was approved through an institutional IRB. Inclusion criteria included: age greater than 18 years of age, corpectomy between T4 and L5, pathology confirmed metastatic disease. Data points included in the analysis were: age, level of metastasis, primary tumor histology, functional outcome, time to ambulation, need for re-operation, and other perioperative complications. Neurologic examination was performed utilizing the ASIA grading system with motor graded on a six-point scale (0-5) and sensation on a three-point scale (0,1,2) for both pin-prick and touch sensation. Postoperative imaging was taken in all cases to evaluate structural stabilization and Shiveindra Jeyamohan, BS1, Alexander Vaccaro, MD, PhD 2, James S Harrop, MD 3 1Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 2 Rothman Institute, Philadelphia, PA 3 Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"142 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Use of Expandable Cages in Metastasis to the Spine\",\"authors\":\"Shiveindra B. Jeyamohan, A. Vaccaro, J. Harrop\",\"doi\":\"10.29046/jhnj.004.4.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Expandable cages have been utilized as an option for immediate spinal stabilization after vertebrectomy. However, long-term follow-up in the oncology population has not been studied, and results remain unclear. This single-institution series of patients represents our success in utilizing expandable cages. Methods: A retrospective chart review for patients with spinal metastasis treated with expandable cages between 2001 and 2006 was performed with IRB approval. Data regarding date of anterior and posterior surgery, immediate postoperative neurological status versus preoperative status, revision, equipment status, pseudoarthrosis, time to ambulation, and mortality were gathered and analyzed. Results: Twenty-four patients with metastatic cancer to the spine were studied. Cages were placed from T5-L5, 21 of which were single level. Of the 24 patients, 5 (21%) were neurologically intact pre-operatively and postoperatively. 13 of the 24 (54%) improved postoperatively. The remaining six (25%) illustrated no change in neurologic status. No patients deteriorated. At two years’ follow-up, overall patient survival was 79%. Average time to ambulation for patients followed was 11.5 days. No revisions were done for hardware failure, while one revision was performed for tumor progression. Conclusions: Expandable cages appear to be a valid treatment option for the immediate stabilization of the spine following corpectomy from spinal metastasis. Results indicate that fast recovery, reasonable long-term mortality, and immediate stabilization are achievable with this modality. Consequently, expandable cages should be considered as a valid option in the treatment for stabilization following corpectomy in metastasis to the spine. Introduction The spinal column is a frequent site of metastatic disease, particularly from lung, prostate, breast, kidney as the primary sources, whereas primary spinal column tumors comprise a minority of spinal pathology (<2%) 4. Although patients may present in a variety of conditions, pathologic fractures or increased axial spinal pain are frequent issues. Surgical treatment for this disease includes decompression of the neural elements, alleviation of painful symptoms, resolution of mechanical instabilization, and resection of the oncologic burden 2. Surgical treatment options for patients with progressive neurologic deterioration include anterior, posterior or combined decompression with subsequent spinal reconstructions. Expandable cages have recently been utilized as a treatment option for spinal reconstruction after vertebrectomy, particularly in the trauma population1. With increased familiarity of these devices, cages are now being utilized after corpectomy from tumor metastasis, but data regarding this treatment option is lacking 2-3. Vertebral body replacement with expandable cages may provide several potential theoretical advantages such as permitting optimal anatomic placement in addition to concurrent correction of spinal deformity. This manuscript consists of a retrospective review of clinical data from expandable cages after corpectomy in spinal metastatic disease. The hypothesis was these devices would be well tolerated and thus a treatment option in this difficult patient population. Clinical Materials and Methods Between June 2001 and November 2006, twenty-four consecutive patients were retrospectively identified through a chart review that underwent expandable cage reconstruction for metastatic disease with pathologic fractures. Patient research protocol was approved through an institutional IRB. Inclusion criteria included: age greater than 18 years of age, corpectomy between T4 and L5, pathology confirmed metastatic disease. Data points included in the analysis were: age, level of metastasis, primary tumor histology, functional outcome, time to ambulation, need for re-operation, and other perioperative complications. Neurologic examination was performed utilizing the ASIA grading system with motor graded on a six-point scale (0-5) and sensation on a three-point scale (0,1,2) for both pin-prick and touch sensation. Postoperative imaging was taken in all cases to evaluate structural stabilization and Shiveindra Jeyamohan, BS1, Alexander Vaccaro, MD, PhD 2, James S Harrop, MD 3 1Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 2 Rothman Institute, Philadelphia, PA 3 Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA\",\"PeriodicalId\":355574,\"journal\":{\"name\":\"JHN Journal\",\"volume\":\"142 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JHN Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29046/jhnj.004.4.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JHN Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29046/jhnj.004.4.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
摘要
导读:椎体切除术后,可膨胀的固定架被用作立即稳定脊柱的一种选择。然而,肿瘤人群的长期随访尚未研究,结果仍不清楚。这个单一机构系列的患者代表了我们在使用可扩展笼方面的成功。方法:回顾性回顾2001年至2006年经IRB批准的脊柱转移患者使用膨胀笼治疗的病例。收集和分析有关前后路手术日期、术后立即神经系统状态与术前状态、翻修、设备状态、假关节、活动时间和死亡率的数据。结果:对24例脊柱转移性肿瘤进行了研究。从T5-L5放置笼子,其中21个为单层。在24例患者中,5例(21%)术前和术后神经功能完整。24例患者中13例(54%)术后改善。其余6例(25%)未见神经状态改变。没有患者病情恶化。在两年的随访中,患者的总生存率为79%。随访患者的平均行走时间为11.5天。没有因硬件故障而进行修订,而因肿瘤进展而进行了一次修订。结论:对于脊柱转移性椎体切除术后的脊柱即刻稳定,可膨胀笼似乎是一种有效的治疗选择。结果表明,该方法可实现快速恢复,合理的长期死亡率和立即稳定。因此,在椎体切除术后转移至脊柱的稳定治疗中,应考虑使用可膨胀的固定架。脊柱是转移性疾病的常见部位,尤其是肺、前列腺、乳腺、肾脏为主要来源,而原发性脊柱肿瘤仅占脊柱病理的少数(<2%)4。尽管患者可能出现多种情况,但病理性骨折或增加的轴向脊柱疼痛是常见的问题。这种疾病的手术治疗包括神经元件的减压、疼痛症状的缓解、机械不稳定的解决和肿瘤负担的切除2。进行性神经功能恶化患者的手术治疗选择包括前路、后路或联合减压并随后进行脊柱重建。近年来,可膨胀笼已被用作椎体切除术后脊柱重建的一种治疗选择,特别是在创伤人群中。随着对这些装置的熟悉程度的提高,笼子现在被用于肿瘤转移的椎体切除术后,但关于这种治疗选择的数据缺乏2-3。椎体置换术中使用可伸缩支架可能提供几个潜在的理论优势,如允许最佳解剖放置,同时矫正脊柱畸形。这篇文章包括对脊柱转移性疾病椎体切除术后可扩展笼的临床资料的回顾性回顾。我们的假设是这些装置耐受性良好,因此是这一困难患者群体的治疗选择。临床资料和方法:2001年6月至2006年11月,通过回顾性的图表回顾,对24例连续患者进行了可扩展笼重建,以治疗转移性疾病并病理性骨折。患者研究方案通过机构内部审查委员会批准。纳入标准为:年龄大于18岁,T4 ~ L5间行椎体切除术,病理证实有转移性疾病。纳入分析的数据点包括:年龄、转移水平、原发肿瘤组织学、功能结果、活动时间、再次手术需要和其他围手术期并发症。神经系统检查采用ASIA评分系统,运动评分为6分制(0-5),针刺和触觉评分为3分制(0、1、2)。所有病例均进行术后成像以评估结构稳定性和Shiveindra Jeyamohan, BS1, Alexander Vaccaro, MD, PhD 2, James S Harrop, MD 3费城托马斯杰斐逊大学杰斐逊医学院,PA 2费城罗夫曼研究所,PA 3费城托马斯杰斐逊大学神经外科
Use of Expandable Cages in Metastasis to the Spine
Introduction: Expandable cages have been utilized as an option for immediate spinal stabilization after vertebrectomy. However, long-term follow-up in the oncology population has not been studied, and results remain unclear. This single-institution series of patients represents our success in utilizing expandable cages. Methods: A retrospective chart review for patients with spinal metastasis treated with expandable cages between 2001 and 2006 was performed with IRB approval. Data regarding date of anterior and posterior surgery, immediate postoperative neurological status versus preoperative status, revision, equipment status, pseudoarthrosis, time to ambulation, and mortality were gathered and analyzed. Results: Twenty-four patients with metastatic cancer to the spine were studied. Cages were placed from T5-L5, 21 of which were single level. Of the 24 patients, 5 (21%) were neurologically intact pre-operatively and postoperatively. 13 of the 24 (54%) improved postoperatively. The remaining six (25%) illustrated no change in neurologic status. No patients deteriorated. At two years’ follow-up, overall patient survival was 79%. Average time to ambulation for patients followed was 11.5 days. No revisions were done for hardware failure, while one revision was performed for tumor progression. Conclusions: Expandable cages appear to be a valid treatment option for the immediate stabilization of the spine following corpectomy from spinal metastasis. Results indicate that fast recovery, reasonable long-term mortality, and immediate stabilization are achievable with this modality. Consequently, expandable cages should be considered as a valid option in the treatment for stabilization following corpectomy in metastasis to the spine. Introduction The spinal column is a frequent site of metastatic disease, particularly from lung, prostate, breast, kidney as the primary sources, whereas primary spinal column tumors comprise a minority of spinal pathology (<2%) 4. Although patients may present in a variety of conditions, pathologic fractures or increased axial spinal pain are frequent issues. Surgical treatment for this disease includes decompression of the neural elements, alleviation of painful symptoms, resolution of mechanical instabilization, and resection of the oncologic burden 2. Surgical treatment options for patients with progressive neurologic deterioration include anterior, posterior or combined decompression with subsequent spinal reconstructions. Expandable cages have recently been utilized as a treatment option for spinal reconstruction after vertebrectomy, particularly in the trauma population1. With increased familiarity of these devices, cages are now being utilized after corpectomy from tumor metastasis, but data regarding this treatment option is lacking 2-3. Vertebral body replacement with expandable cages may provide several potential theoretical advantages such as permitting optimal anatomic placement in addition to concurrent correction of spinal deformity. This manuscript consists of a retrospective review of clinical data from expandable cages after corpectomy in spinal metastatic disease. The hypothesis was these devices would be well tolerated and thus a treatment option in this difficult patient population. Clinical Materials and Methods Between June 2001 and November 2006, twenty-four consecutive patients were retrospectively identified through a chart review that underwent expandable cage reconstruction for metastatic disease with pathologic fractures. Patient research protocol was approved through an institutional IRB. Inclusion criteria included: age greater than 18 years of age, corpectomy between T4 and L5, pathology confirmed metastatic disease. Data points included in the analysis were: age, level of metastasis, primary tumor histology, functional outcome, time to ambulation, need for re-operation, and other perioperative complications. Neurologic examination was performed utilizing the ASIA grading system with motor graded on a six-point scale (0-5) and sensation on a three-point scale (0,1,2) for both pin-prick and touch sensation. Postoperative imaging was taken in all cases to evaluate structural stabilization and Shiveindra Jeyamohan, BS1, Alexander Vaccaro, MD, PhD 2, James S Harrop, MD 3 1Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 2 Rothman Institute, Philadelphia, PA 3 Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA