{"title":"针对癌症中SWI/SNF代谢脆弱性","authors":"M. Soeung, L. Perelli, A. Sgambato, G. Genovese","doi":"10.48286/aro.2021.31","DOIUrl":null,"url":null,"abstract":"The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting SWI/SNF metabolic vulnerabilities in cancer\",\"authors\":\"M. Soeung, L. Perelli, A. Sgambato, G. Genovese\",\"doi\":\"10.48286/aro.2021.31\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA\",\"PeriodicalId\":148778,\"journal\":{\"name\":\"Annals of Research in Oncology\",\"volume\":\"15 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Research in Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.48286/aro.2021.31\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Research in Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.48286/aro.2021.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
SWI/SNF(开关/蔗糖不可发酵)复合物是一个关键的表观遗传调控因子，在不同物种中是保守的。虽然其作为基因表达调节剂的功能已被广泛表征，但新的证据表明，它可以在生理和病理过程中作为代谢途径的基本调节剂。在这篇综述中，我们总结了涉及SWI/SNF复合体成员和代谢途径的分子相互作用的最新文献。我们关注的是遗传如何1基因组医学部，德克萨斯大学MD安德森癌症中心，休斯顿，德克萨斯州，美国2生殖泌尿医学肿瘤科，德克萨斯大学MD安德森癌症中心，休斯顿，德克萨斯州，美国3转化医学和外科，罗马，意大利4科学方向，巴西巴西肿瘤研究中心，ircs - crob，里奥内罗在Vulture, Potenza，5德克萨斯大学MD安德森癌症中心，生殖泌尿系统癌症应用研究David H. Koch中心，休斯顿，德克萨斯州，美国
Targeting SWI/SNF metabolic vulnerabilities in cancer
The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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