Speed Efficient Fast Fourier Transform for Signal Processing of Nucleotides to Detect Diabetic Retinopathy Using Machine Learning

Diabetic Retinopathy (DR) is a complicated disease of diabetes, which specifically affects the retina. The human-intensive analysis mechanism of DR infected retina are likely to diagnose wrongly compared to computer-intensive diagnosis systems. In this paper, in order to aid the computer based approach for the diagnosis of DR, a model based on machine learning algorithm is proposed. The nucleotides of the human retina are processed with the help of signal processing methodologies. A speed efficient Fast Fourier transform is proposed to work out the FFT of huge amount of samples with higher pace. The improvement in speed is achieved in 98% of the samples. The prediction parameters, derived from these samples are utilized to classify the healthy retina sequence and an infected retina. In this study, Fine Tree, KNN Fine, Weighted KNN, Ensemble Bagged Trees and Ensemble Subspace KNN classifiers are employed to build the models. The simulated results using MATLAB software show that the accuracy is 98% which is better than image processing based methods which were used earlier. The performance parameters such as sensitivity and specificity are determined for each model. The faithfulness of the model is studied by deriving the ROC Curve.