SARS-CoV-2病毒载量预测COVID-19死亡率

E. Pujadas, Fayzan F. Chaudhry, Russell B McBride, F. Richter, Shan P Zhao, A. Wajnberg, G. Nadkarni, Benjamin S. Glicksberg, J. Houldsworth, C. Cordon-Cardo
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引用次数: 426

摘要

对可靠和广泛可用的SARS-CoV-2检测的需求是众所周知的,但同样有必要开发确定病毒载量的定量方法,以指导患者分诊和医疗决策。我们首次报道了在一项大型患者队列(n= 1145)中,就诊时的SARS-CoV-2病毒载量是COVID-19死亡率的独立预测因子。病毒载量应用于识别可能需要更积极治疗的高风险患者,并应作为预测算法开发中的关键生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SARS-CoV-2 viral load predicts COVID-19 mortality
The need for reliable and widely available SARS-CoV-2 testing is well recognized, but it will be equally necessary to develop quantitative methods that determine viral load in order to guide patient triage and medical decision making. We are the first to report that SARS-CoV-2 viral load at the time of presentation is an independent predictor of COVID-19 mortality in a large patient cohort (n=1,145). Viral loads should be used to identify higher-risk patients that may require more aggressive care and should be included as a key biomarker in the development of predictive algorithms.
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