书评:《非凡科学与精神病学:对心理健康研究危机的回应》

P. Grof
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The authors feel that the recent hot debates surrounding the DSM-5 indicate in particular that in psychiatry, there are now major tensions between clinical and research aims, as well as controversies over diagnoses and treatments. Many critics have found the DSM unusable for research and feel it is linked to the notable paucity of progress; some consider it also flawed for clinical practice. The overriding concern is that the mental disorder constructs found in the DSM are not appropriate for scientific research. The DSM categories are seen as too general and too symptom based, leading to heterogeneity. They overlap and the boundaries are loose. There are problems with the validity and reliability of psychiatric diagnoses, heterogeneity of the resulting groupings, confusing comorbidities, inclusiveness of criteria, and overlap with normality. The main goal of the book is to help reconcile the competing directions and to explore the ways that may lead out of this dilemma. 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After reviewing the evidence, he finds in particular insufficient evidence for using bipolar classification in young children. Several contributors point out that the probing of dominant thinking and the emergence of alternative initiatives suggest an epoch that Thomas Kuhn characterised as “extraordinary science.” It includes both intense attempts to defend the prevailing paradigm (as expressed particularly in the DSM) as well as probing research results that do not fit the present concepts and exploring alternative research frameworks. The book contains multiple proposals on what would constitute an adequate response to this situation. Several approaches appear promising, but no consensus has been achieved. Let me mention a few examples: probing the problems exhibited by DSM categories, targeting various aspects of mental illness in novel ways, and integrating resources from a broader range of relevant sciences. 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引用次数: 0

摘要

毫无疑问,精神病学诊断是精神病学研究和临床实践的核心。这本书最初的动力来自于圣地亚哥的一次精神病学分类学研讨会。后来又邀请了其他贡献者加入作者的行列。这本书借用了托马斯·库恩(Thomas Kuhn)的名字“非凡的科学”(extraordinary science),他为范式变化期间的科学研究创造了这个词。作者贡献的卷探索的性质和来源的目前的问题和可能的出路。虽然这本书是精神病学研究人员的必读之作,但它也为对诊断过程感兴趣的临床医生提供了很多东西。作者认为,最近围绕DSM-5的激烈争论尤其表明,在精神病学领域,临床和研究目标之间存在重大紧张关系,在诊断和治疗方面也存在争议。许多批评人士发现DSM无法用于研究,并认为它与显著缺乏进展有关;一些人认为它在临床实践中也存在缺陷。最主要的担忧是,DSM中发现的精神障碍结构不适合科学研究。DSM分类被认为过于笼统,过于以症状为基础,导致异质性。它们重叠,边界很松散。精神病学诊断的有效性和可靠性、结果分组的异质性、混淆的合并症、标准的包容性以及与正常情况的重叠都存在问题。这本书的主要目标是帮助调和相互竞争的方向,并探索可能导致这种困境的方式。贡献者包括心理健康研究人员和科学哲学家。他们讨论了当前争议的起源,探讨了精神病学研究中证据的重要性,并批评了美国国家精神卫生研究所(NIMH)提出的用他们自己的研究类别(RDoC)取代DSM诊断的建议。对于临床医生来说,特别感兴趣的将是理查德·本特尔关于精神分裂症的章节和哈罗德·金凯关于双相情感障碍的章节。本特尔提供了精神分裂症概念的简史,并证明了关于精神分裂症本质的流行的、广泛的假设并没有纳入所有可用的证据。他给出了一种解释,研究人员可能对不符合预期的数据视而不见,最终保护了现有的范式。金凯德将他的分析集中在重度抑郁症和双相情感障碍上,因为他们有大量的研究发现。在回顾证据后,他发现在幼儿中使用双相情感障碍分类的证据尤其不足。几位撰稿人指出,对主导思想的探索和另类倡议的出现表明了一个被托马斯·库恩描述为“非凡科学”的时代。它既包括捍卫主流范式(特别是在DSM中所表达的)的强烈尝试,也包括探究不符合当前概念的研究结果和探索替代研究框架。这本书包含了关于如何对这种情况作出适当反应的多项建议。有几种方法看起来很有希望,但尚未达成共识。让我举几个例子:探索DSM分类所显示的问题,以新颖的方式针对精神疾病的各个方面,以及整合来自更广泛的相关科学的资源。然而,在其他地方,也有人支持对DSM进行更多的修改和修补,为此已经成立了一个新的委员会。正如我们所知,其他人一起推动了对DSM项目的拒绝。当然,对于如何最好地处理社会文化背景下与心理健康相关的多面、多维复杂性问题,目前还没有达成一致意见。但是,目前的情况确实为对精神病学研究和诊断实践的基础进行批判性检查提供了一个重要的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Book Review: Extraordinary Science and Psychiatry: Responses to the Crisis in Mental Health Research
Undoubtedly, psychiatric diagnoses are central to psychiatric research and clinical practice. The initial impetus for this book came from a symposium on psychiatric taxonomy in San Diego. Later additional contributors were invited to join the authors. The book borrows the title “extraordinary science” from Thomas Kuhn, who coined this term for scientific research that is taking place during the paradigm change. The authors contributing to the volume explore the nature and sources of the present problems and possible ways out. While the book is a must-read for psychiatric researchers, it also has much to offer to clinicians interested in the diagnostic process. The authors feel that the recent hot debates surrounding the DSM-5 indicate in particular that in psychiatry, there are now major tensions between clinical and research aims, as well as controversies over diagnoses and treatments. Many critics have found the DSM unusable for research and feel it is linked to the notable paucity of progress; some consider it also flawed for clinical practice. The overriding concern is that the mental disorder constructs found in the DSM are not appropriate for scientific research. The DSM categories are seen as too general and too symptom based, leading to heterogeneity. They overlap and the boundaries are loose. There are problems with the validity and reliability of psychiatric diagnoses, heterogeneity of the resulting groupings, confusing comorbidities, inclusiveness of criteria, and overlap with normality. The main goal of the book is to help reconcile the competing directions and to explore the ways that may lead out of this dilemma. Contributors include mental health researchers and philosophers of science. They discuss the origins of the current controversies, explore the weight of evidence in psychiatric research, and criticise the National Institute of Mental Health (NIMH) proposal to replace DSM diagnoses by their own research categories (RDoC). For clinicians, of particular interest will be the chapters by Richard Bentall on schizophrenia and Harold Kincaid’s chapter on bipolar disorder. Bentall provides a brief history of the schizophrenia concept and demonstrates that the prevailing, widespread assumptions about the nature of schizophrenia do not incorporate all the available evidence. He offers an explanation that researchers may be blind to data that do not fit the expectations and end up protecting the existing paradigm. Kincaid centers his analysis on major depressive disorder and bipolar disorder as they have grounded substantial research findings. After reviewing the evidence, he finds in particular insufficient evidence for using bipolar classification in young children. Several contributors point out that the probing of dominant thinking and the emergence of alternative initiatives suggest an epoch that Thomas Kuhn characterised as “extraordinary science.” It includes both intense attempts to defend the prevailing paradigm (as expressed particularly in the DSM) as well as probing research results that do not fit the present concepts and exploring alternative research frameworks. The book contains multiple proposals on what would constitute an adequate response to this situation. Several approaches appear promising, but no consensus has been achieved. Let me mention a few examples: probing the problems exhibited by DSM categories, targeting various aspects of mental illness in novel ways, and integrating resources from a broader range of relevant sciences. Elsewhere, however, there are proponents of more revising and tinkering with DSM, an approach for which a new committee has already been set up. Others, as we know, pushed towards the rejection of the DSM project together. Definitely, there is not yet accord about how to best deal with the multifaceted, multidimensional complexity of mental health–related issues embedded in sociocultural contexts. But the current situation certainly provides an important opportunity for a critical examination of the foundations of psychiatric research and diagnostic practices.
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