运动可以减少瘦素对肥胖的影响

Putu Adi Suputra
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引用次数: 0

摘要

肥胖是一个世界性的健康问题,与高血压、糖尿病和癌症有关。不健康和过度的饮食、低体力活动和久坐不动的生活方式是肥胖的危险因素。肥胖会导致脂肪因子功能紊乱,其中之一就是瘦素。众所周知,瘦素在代谢稳态的调节中发挥作用,特别是在肥胖中。肥胖中的高瘦素血症是由瘦素抵抗引起的,这是能量摄入过多和缺乏身体活动或锻炼的结果,导致循环中瘦素水平过高。有规律的体育锻炼通过调节下丘脑中参与信号转导途径的几种蛋白质来改善瘦素信号传导。体育锻炼还可以减少下丘脑的炎症或起到消炎的作用。内质网应激与下丘脑炎症和胰岛素和瘦素信号传导失败有关。中、高强度有氧运动和阻力训练≥12周,运动频率为每周3-4次,对瘦素抵抗的改善效果更好。急性运动和<12周的运动对降低肥胖患者的瘦素水平不是很有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise to reduce leptin on obesity
Obesity is a worldwide health problem associated with hypertension, diabetes, and cancer. An unhealthy and excessive diet, low physical activity, and a sedentary lifestyle are risk factors for obesity. Obesity causes adipokine dysfunction, one of which is leptin. Leptin is known to play a role in the regulation of metabolic homeostasis, especially in obesity. Hyperleptinemia in obesity is caused by leptin resistance, the result of excess energy intake and lack of physical activity or exercise, causing high levels of leptin in circulation. Regular physical exercise improves leptin signalling by regulating several proteins involved in signal transduction pathways in the hypothalamus. Physical exercise also reduces inflammation in the hypothalamus or acts as an anti-inflammatory. Stress on the endoplasmic reticulum is associated with hypothalamic inflammation and failure of insulin and leptin signalling. Improvement of leptin resistance is more effective in moderate and high-intensity aerobic exercise as well as resistance training carried out for >12 weeks with a frequency of exercise 3-4 times a week. Acute exercise and <12 weeks of exercise are not very effective in reducing leptin levels in obesity.
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