Use of creatine for muscle hypertrophy in resistance training practitioners: a narrative review

Creatine is a natural substance found in muscles that has gained popularity among physical activity practitioners, especially bodybuilders, due to its various benefits, including improved muscle tone, increased strength, optimized recovery, and muscle mass gain. The most common form of creatine is monohydrate, which is cost-effective and efficacious. However, the unguided use of supplements, including α-methyl guanidinoacetic acid, which has possible pharmacological, nutritional, and physiological effects on fast muscle energy and muscle hypertrophy, is common among exercise practitioners. On the other hand, creatine, also a widely used ergogenic, is capable of rapidly renewing muscular energy and increasing strength and total lean body mass. However, the use of dietary supplements such as creatine should be done with caution and accompanied by a specialized professional capable of establishing parameters that best meet the individual needs of each athlete or individual seeking muscle hypertrophy. It is essential to discuss the factors associated with the development of lean muscle mass, including creatine supplementation, considering its nutritional and pharmacological implications. Therefore, this narrative review aims to analyze the role of creatine as an ergogenic dietary supplement for muscle hypertrophy and identify the risks associated with its consumption.