考虑血浆未结合分数和临床C_max的hERG IC_50治疗指标的数学推导

Drug information journal : DIJ / Drug Information Association Pub Date : 2012-09-01 DOI:10.1177/0092861512456285

R. Fryer

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引用次数: 1

摘要

为临床候选人提供了一些关于什么是合适的治疗指数(TI)来减轻herg介导的心律失常风险的指南。不管实际需要的TI是多少，考虑到通常归属于IC的不同单位，在如何计算这个值方面，有时存在一定程度的混淆

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Mathematical Derivation of Therapeutic Index Based on hERG IC_50 Taking Into Account Fraction Unbound in Plasma and Clinical C_max

have offered some guidelines regarding what might bedeemed an appropriate therapeutic index (TI) to mitigate therisk of hERG-mediated arrhythmias for clinical candidates.Regardless of the actual TI desired, there is, at times, a degreeof confusion regarding how to calculate this value given the dif-ferent units oftentimes ascribed to an IC

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Drug information journal : DIJ / Drug Information Association

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