利用新一代测序数据跟踪SARS-CoV-2病毒突变进化和物种形成的机器学习模型

I. Derecichei, G. Atikukke
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引用次数: 2

摘要

新发SARS-CoV-2感染的RNA序列分析对于追踪病毒进化和开发新的诊断工具具有重要价值。此外,SARS-CoV-2序列分析可以深入了解导致菌株物种形成和改变临床结果的潜在抗原漂移事件。在这项工作中,我们的目标是利用下一代测序(NGS)技术以及机器学习/生物信息学开发一个管道,以跟踪突变的积累和病毒的进化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Machine Learning Model to Track SARS-CoV-2 Viral Mutation Evolution and Speciation Using Next-generation Sequencing Data
RNA sequence analysis of emerging SARS-CoV-2 infection is valuable for tracking viral evolution and developing novel diagnostic tools. Furthermore, SARS-CoV-2 sequence analysis can provide insight into potential antigenic drift events that lead to strain speciation and changing clinical outcomes. In this work, we aim to develop a pipeline using next-generation sequencing (NGS) technology in addition to machine learning/bioinformatics to track the accumulation of mutations and viral evolution.
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