脂质体作为治疗家畜细菌和寄生虫感染的新途径

Ferro Cavalcanti Isabella Macário
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引用次数: 0

摘要

众所周知,寄生虫感染和细菌感染,特别是由对抗菌素具有耐药性的细菌引起的感染,在全世界的家畜中造成了很高的发病率和死亡率。用于治疗这些感染的药物可能存在毒性和低生物利用度,延迟了这些动物的恢复过程。在此背景下,纳米技术作为开发这些药物的新有效药物剂型的新方法出现,旨在更好的生物分布和减少不良事件。纳米载体,如脂质体,由于其生物相容性、可生物降解性和低毒性,在递送生物活性物质方面具有很大的潜力。脂质体可用于各种领域,包括兽医学,并在近几十年来取得了巨大的进步。因此,本研究旨在强调关于脂质体作为药物纳米载体在治疗家畜寄生虫和细菌感染方面的巨大潜力的主要和最新科学发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liposomes as New Approaches in the Treatment of Bacterial and Parasitic Infections in Domestic Animals
Parasitic infections and bacterial infections, especially those caused by bacteria resistant to antimicrobial agents, are known to provide high morbidity and mortality rates in domestic animals worldwide. The drugs used in the treatment of these infections may present toxicity and low bioavailability, delaying the recovery process of these animals. In this context, nanotechnology appears as a new approach for the development of new effective pharmaceutical dosage forms of these drugs, aiming a better biodistribution and decrease of adverse events. Nanocarriers, such as liposomes, have great potential for the delivery of bioactive substances due to their biocompatibility, biodegradability and low toxicity. Liposomes can be used in a variety of fields, including veterinary medicine, and have made great strides in recent decades. Thus, the present study aims to highlight the main and most recent scientific discoveries about the promising potential of liposomes as nanocarriers of drugs in the treatment of parasitic and bacterial infections in domestic animals.
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