2,4,6-三氯苯-4′-氨基苯基醚在鲤鱼体内的积累和代谢。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1990-01-01

T Tsuda, S Aoki, M Kojima, H Harada

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摘要

1. 研究了2,4,6-三氯苯基-4′-氨基苯基醚(CNP-amino)在鲤鱼体内14天的积累情况。鲤鱼体内的CNP-amino可分为游离CNP-amino [CNP-amino(I)]和结合CNP-amino [CNP-amino(II)]。2. 暴露14 d后，鲤鱼肌肉、肝脏、肾脏和胆囊的cnp -氨基(I + II)生物浓度因子(BCF)分别为90 +/- 38(平均+/- SD, n = 3)、402、501和5368。3.2,4,6-三氯苯基-4′-乙酰氨基苯醚(CNP-acetamide)是鲤鱼肌肉和内脏中cnp -氨基的代谢物。

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Accumulation and metabolism of 2,4,6-trichlorophenyl-4'-aminophenyl ether by carp.

1. Accumulation of 2,4,6-trichlorophenyl-4'-aminophenyl ether (CNP-amino) in carp was investigated for 14 days. CNP-amino in carp could be divided into free CNP-amino [CNP-amino(I)] and bound CNP-amino [CNP-amino(II)]. 2. The bioconcentration factors (BCF) of CNP-amino(I + II) in carp were 90 +/- 38 (mean +/- SD, n = 3) for muscle, 402 for liver, 501 for kidney and 5368 for gallbladder after 14 days exposure. 3. 2,4,6-Trichlorophenyl-4'-acetamide phenyl ether (CNP-acetamide) was detected as metabolites of CNP-amino in muscle and viscera of carp.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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