乳酪蛋白胰酶水解物对自发性高血压大鼠的降压作用。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1990-01-01

H Karaki, K Doi, S Sugano, H Uchiwa, R Sugai, U Murakami, S Takemoto

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引用次数: 0

摘要

1. 反复口服牛乳酪蛋白(CEI)对自发性高血压大鼠有明显的降压作用。2. 单次口服CEI可拮抗血管紧张素i的升压反应。牛乳酪蛋白水解物对血管紧张素i转换酶(ACE)活性有抑制作用。从CEI中分离到3个具有ace抑制活性的肽段。4. 提示胰蛋白酶水解乳酪蛋白中的ace抑制肽可从肠道吸收并产生降压作用。

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Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats.

1. Repeated oral administrations of tryptic hydrolysate of bovine milk casein (CEI) showed antihypertensive effect in spontaneously hypertensive rats. 2. Single oral administration of CEI antagonized the pressor response to angiotensin I. 3. Bovine milk casein hydrolysate inhibited the angiotensin I-converting enzyme (ACE) activity. Three peptides with ACE-inhibiting activity were isolated from CEI. 4. It is suggested that ACE-inhibiting peptides in the tryptic hydrolysate milk casein are absorbed from the intestinal tract and produce an antihypertensive effect.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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