{"title":"头孢曲松与诺氟沙星治疗儿童耐药伤寒60例比较","authors":"Youwei Huai, Qirong Zhu","doi":"10.3760/CMA.J.ISSN.0578-1310.2000.06.121","DOIUrl":null,"url":null,"abstract":"Objective \nTo compare the effect of ceftriaxone and norfloxacin on resistant typhoid fever in children. \n \n \nMethods \nSixty children with typhoid fever resistant to chloramphenicol, ampicillin or cotrimoxazole were randomly divided into two groups. Thirty cases received ceftriaxone [100 mg/ (kg·d) , once daily, iv] and the other 30 received norfloxacin [10 mg/ (kg·d) , twice daily] . \n \n \nResult \nCeftriaxone was effective in 93% of the 30 cases, while norfloxacin was effective in 80% of the 30 cases (Ridit analysis, ceftriaxon (R = 0.421 1, norfloxacin (R = 0.578 9, u = 2.12, P <0.05) . \n \n \nConclusion \nThe therapeutic effect of ceftriaxone on drug-resistant typhoid fever in children was better than that of norfloxacin. \n \n \nKey words: \nTyphoid; Ceftriaxone; Norfloxacin; Child","PeriodicalId":416525,"journal":{"name":"Chinexe Journal of Pediatrics","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2000-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Ceftriaxone vs. norfloxacin in the treatment of resistant typhoid fever in 60 children\",\"authors\":\"Youwei Huai, Qirong Zhu\",\"doi\":\"10.3760/CMA.J.ISSN.0578-1310.2000.06.121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo compare the effect of ceftriaxone and norfloxacin on resistant typhoid fever in children. \\n \\n \\nMethods \\nSixty children with typhoid fever resistant to chloramphenicol, ampicillin or cotrimoxazole were randomly divided into two groups. Thirty cases received ceftriaxone [100 mg/ (kg·d) , once daily, iv] and the other 30 received norfloxacin [10 mg/ (kg·d) , twice daily] . \\n \\n \\nResult \\nCeftriaxone was effective in 93% of the 30 cases, while norfloxacin was effective in 80% of the 30 cases (Ridit analysis, ceftriaxon (R = 0.421 1, norfloxacin (R = 0.578 9, u = 2.12, P <0.05) . \\n \\n \\nConclusion \\nThe therapeutic effect of ceftriaxone on drug-resistant typhoid fever in children was better than that of norfloxacin. \\n \\n \\nKey words: \\nTyphoid; Ceftriaxone; Norfloxacin; Child\",\"PeriodicalId\":416525,\"journal\":{\"name\":\"Chinexe Journal of Pediatrics\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinexe Journal of Pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.0578-1310.2000.06.121\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinexe Journal of Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0578-1310.2000.06.121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
摘要
目的比较头孢曲松与诺氟沙星治疗儿童耐药伤寒的疗效。方法将60例对氯霉素、氨苄西林、复方新诺明耐药的伤寒患儿随机分为两组。30例给予头孢曲松[100 mg/ (kg·d)，每日1次，静脉注射]，30例给予诺氟沙星[10 mg/ (kg·d)，每日2次]。结果30例患者中头孢曲松有效率为93%，诺氟沙星有效率为80% (Ridit分析，头孢曲松(R = 0.421 1)，诺氟沙星(R = 0.578 9, u = 2.12, P <0.05)。结论头孢曲松治疗儿童耐药伤寒的疗效优于诺氟沙星。关键词:伤寒;头孢曲松钠;诺氟沙星;孩子
Ceftriaxone vs. norfloxacin in the treatment of resistant typhoid fever in 60 children
Objective
To compare the effect of ceftriaxone and norfloxacin on resistant typhoid fever in children.
Methods
Sixty children with typhoid fever resistant to chloramphenicol, ampicillin or cotrimoxazole were randomly divided into two groups. Thirty cases received ceftriaxone [100 mg/ (kg·d) , once daily, iv] and the other 30 received norfloxacin [10 mg/ (kg·d) , twice daily] .
Result
Ceftriaxone was effective in 93% of the 30 cases, while norfloxacin was effective in 80% of the 30 cases (Ridit analysis, ceftriaxon (R = 0.421 1, norfloxacin (R = 0.578 9, u = 2.12, P <0.05) .
Conclusion
The therapeutic effect of ceftriaxone on drug-resistant typhoid fever in children was better than that of norfloxacin.
Key words:
Typhoid; Ceftriaxone; Norfloxacin; Child
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
