抗炎药对大鼠肝肾抗氧化酶及体内过氧化产物活性的影响。

L Weglarz, M Drózdz, M Goss
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引用次数: 0

摘要

1. 四组大鼠分别注射吲哚美辛、苯丁酮、乙酰水杨酸和氢化可的松四种不同的抗炎药物,研究肝、肾超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。2. 与对照动物相比,药物治疗导致两个器官中酶的活性降低。3.体内组织过氧化作用也受到药物作用的影响。4. 我们的研究结果表明,氧自由基代谢的变化有助于这些药物在体内的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of anti-inflammatory drugs on the activity of antioxidant enzymes and in vivo peroxidation products in the liver and kidney of rat.

1. Four groups of rats were injected with four different anti-inflammatory drugs (indomethacin, phenylbutazone, acetylsalicylic acid and hydrocortisone) and the activities of superoxide dismutase, catalase and glutathione peroxidase were studied in the liver and kidney. 2. The drugs treatment resulted in decreased activity of the enzymes in both organs compared to the control animals. 3. In vivo tissue peroxidation was also effected by the drugs used. 4. Our results indicate that the changes of oxygen free-radical metabolism contribute to the action of these drugs in vivo.

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