HPV DNA芯片和混合捕获II检测在阴道镜异常患者中的临床疗效比较

Tae‐Jung Kim, C. Jung, Ahwon Lee, E. Jung, Y. Choi, Kyo‐Young Lee, Jong Sup Park
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引用次数: 2

摘要

本研究比较了DNA芯片法和Hybrid-Capture II法(HC-II)在宫颈上皮内病变患者中检测人乳头瘤病毒的效果。2005年5月至2006年6月,对192例阴道镜检查结果异常的患者行宫颈细胞学检查、HC-II和HPV DNA芯片检测、阴道镜活检或锥切术。我们将HC-II和HPV DNA芯片的结果与宫颈细胞学(LBCC)相结合进行比较,并证实活检或锥化的结果。HPV DNA芯片检测的敏感性高于HC-II和LBCC。HPV DNA芯片联合LBCC的灵敏度高于任何单一方法,也高于HC-II联合LBCC的灵敏度。我们证实HPV DNA芯片检测在宫颈病变中检测HPV比HC-II更敏感,并且它将提供关于HPV类型及其多重感染的更有用的临床信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Clinical Efficacy between an HPV DNA Chip and a Hybrid-Capture II Assay in a Patient with Abnormal Colposcopic Findings
This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.
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