拟南芥的同源基因和单基因

Luca Ambrosino, H. Bostan, Pasquale di Salle, Mara Sangiovanni, A. Vigilante, M. Chiusano
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引用次数: 10

摘要

拟南芥(Arabidopsis thaliana)是植物生物学中公认的模式物种。由于其体积小且具有二倍体性,因此在植物中首次对其基因组进行了测序,使其成为植物比较基因组学的参考物种。然而,形成拟南芥基因组的进化机制仍然存在争议。事实上,复制、易位、倒位和基因丢失事件导致了目前的组织结构,这些都很难追踪。对同源基因和单拷贝基因的可靠鉴定对于理解这些机制至关重要。因此,我们实施了一个专门的管道来识别平行基因,并将单拷贝基因分类到适当的类别。PATsi是一个可通过网络访问的数据库,其组织目的是允许直接访问组织成网络的类似物,并对单拷贝基因进行分类。这允许有效地探索基因收集拟南芥的进化研究和比较基因组学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
pATsi: Paralogs and Singleton Genes from Arabidopsis thaliana
Arabidopsis thaliana is widely accepted as a model species in plant biology. Its genome, due to its small size and diploidy, was the first to be sequenced among plants, making this species also a reference for plant comparative genomics. Nevertheless, the evolutionary mechanisms that shaped the Arabidopsis genome are still controversial. Indeed, duplications, translocations, inversions, and gene loss events that contributed to the current organization are difficult to be traced. A reliable identification of paralogs and single-copy genes is essential to understand these mechanisms. Therefore, we implemented a dedicated pipeline to identify paralog genes and classify single-copy genes into opportune categories. PATsi, a web-accessible database, was organized to allow the straightforward access to the paralogs organized into networks and to the classification of single-copy genes. This permits to efficiently explore the gene collection of Arabidopsis for evolutionary investigations and comparative genomics.
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