A new approach to non-invasive blood glucose measurement based on 2 dimension photoacoustic spectrum

Diabetes mellitus (DM) is worldwide health concern whose complication leads to death. Stabbing finger as prevalent monitoring method brings pain and risk of infection to the patient. Photoacoustic technique is employed to determinate the concentration of blood glucose non-invasively due to its advantage of avoiding the disturbance of optical scattering. But until now there is still no breakthrough on non-invasive blood glucose determination. The problem is that there is not only glucose in human blood but also a lot of other interference elements such as protein, fat and so on. These elements could interfere determination and cause accurate and useful information lost. To solve this problem, we proposed a new approach: using 2 dimension spectrum of photoacoustic extracting multi information of photoacoustic signal which mean combing optical spectrum and sound spectrum. This could improve the specificity and accuracy of detection. This paper describes the theory of photoacoustic and the dual-spectral method of photoacoustic. The experiment system is built to verify the 2 dimension spectrum method used in concentration determination. The experiment result shows that dual-spectrum of photoacoustic method can realize non-invasive photoacoustic blood glucose measurement.