Dysregulated immune response in obese patients aggravated by COVID-19

immune response caused by obesity is amplified when associated with COVID-19, since it enhances the creation of a low-grade local inflammatory microenvironment induced by dysfunctional adipocyte secretions. Likewise, obese patients are more susceptible to SARS-CoV-2 infection due to the gradual loss of functional ASC that impairs ciliogenesis, thus reducing their elimination; also, the altered adipose tissue favors the overexpression of protease receptors that will facilitate their entry. The worsening of the clinical picture of COVID-19 will be triggered as a consequence of the processes of endothelial dysfunction and decreased angiogenesis since, together, they will produce hypoxia, fibrosis and pulmonary functional insufficiency. It is concluded that the dysregulated immune response in obese patients is closely related to morbidity and mortality at the cardio-metabolic level, which leads to a severe clinical picture and in some cases, the death of the infected patient.