小鼠乳腺肿瘤病毒和其他逆转录病毒的翻译移码抑制。

Enzyme Pub Date : 1990-01-01 DOI:10.1159/000468768
J Majors
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引用次数: 2

摘要

逆转录病毒、相关的逆转录子和一些RNA病毒在表达聚合酶基因时使用翻译移框。我们使用逆转录病毒,特别是小鼠乳腺肿瘤病毒,来说明反映我们目前对这些位点特异性移帧事件的理解的模型。该模型有两个组成部分,一个是促进核糖体滑移的移位序列,第二个信号,要么是RNA二级结构,要么是未填充的核糖体a位点,它会使核糖体停滞,并增加在移位位点上滑移的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Translational frameshift suppression in mouse mammary tumor virus and other retroviruses.

Retroviruses, related retroposons, and several RNA viruses use translational frameshifting in the expression of their polymerase genes. We use retroviruses, particularly mouse mammary tumor virus, to illustrate the model which reflects our current understanding of these site-specific frameshifting events. The model has two components, a shifty sequence that facilitates ribosome slippage, and a second signal, either RNA secondary structure or an unfilled ribosomal A site, that stalls the ribosome and increases the probability of slippage at the shifty site.

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