Proof-of-principle validation of a novel intraluminal optical sensor for dynamic monitoring of intestinal anastomosis: An in vivo animal model case study

Intestinal resections are commonly performed to treat different colorectal conditions, including colorectal cancer. A successful primary anastomosis is the desired optimal outcome after intestinal resection. Maintaining adequate blood flow across the anastomosis is paramount for reducing anastomotic failure. Currently, there are no clinical devices capable of continuously assessing blood flow and blood perfusion at an anastomosis during and after surgery. The aim of this study was to develop an indwelling optical sensor for the monitoring of perfusion biomarkers using photoplethysmography and near-infrared spectroscopy principles. In an animal in-vivo proof-of-principle study, it was found that the developed sensor performed appropriately for the assessment of blood flow and perfusion in an anastomosis, showing changes in the assessed parameters after gradual devascularization of the transected bowel.