外耳道肿块:一系列鳞状细胞癌一例

Mel Valerie B. Cruz-Ordinario, Edgar Christian S. Cuaresma, Margarita D. Guevarra, Elsie L. Lim, M. Imasa
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引用次数: 0

摘要

简介:颞骨鳞状细胞癌极为罕见,占头颈部所有肿瘤的0.2%。症状是非特异性的,可能被误认为是其他更良性的疾病,如中耳炎、胆脂瘤和息肉。因此,这种情况可能是一种诊断挑战。病例讨论:我们描述了一个病例系列的三个病人谁提出外耳道(EAC)肿块。最常见的体征和症状是瘙痒、听力下降和淡黄色分泌物。他们最初使用抗生素治疗,但效果不明显。第一例患者是一名51岁的女性,她接受了右耳道和中耳肿块的广泛切除和右侧颞叶开颅手术。组织病理显示中分化鳞状细胞癌伴颞部肿瘤及硬膜下延伸,符合转移。第二例为一名53岁男性,拒绝手术治疗。患者不服从检查和随访,后来出现左脸不对称和头痛。CT扫描显示左侧内耳和中耳道肿块,延伸至听道并突出至左侧小脑半球。左侧EAC肿块行穿刺活检,病理报告为高分化鳞状细胞癌。最后,一位54岁男性接受根治性乳突切除术,病理报告为中度分化鳞状细胞癌。结论:由于本病罕见,标准治疗方式尚不明确。然而,手术切除阴性切缘后同时进行化疗和放疗是最常用的方法1。上述患者均同时给予化疗和放疗,治疗效果显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
External Auditory Canal Mass: A Case Series of Squamous Cell Carcinoma
Introduction: Squamous cell carcinoma of the temporal bone is extremely rare comprising 0.2% of all tumors of head and neck. Symptoms are nonspecific and may be mistaken for other more benign conditions as otitis, cholesteatoma and polyp. Hence, this condition may present as a diagnostic challenge. Case Discussion: We describe a case series of three patients who presented with external auditory canal (EAC) mass. The most common signs and symptoms are pruritus, decreased hearing and yellowish discharge. They were initially treated with otic antibiotics which afforded no relief. The first case is a 51 year-old female who underwent wide excision of the right ear canal and middle ear mass and right temporal craniotomy. Histopathology showed moderately differentiated squamous cell carcinoma with temporal tumor and subdural extension consistent with metastasis. The second case is a 53 year-old male who refused surgical management. He was non-compliant with work-up and follow-up and later on presented with left facial asymmetry and headache. CT scan showed a left inner and middle ear canal mass with extension to the auditory canal and protrusion into the left cerebellar hemisphere. Punch biopsy of the left EAC mass was done and pathologic report showed well-differentiated squamous cell carcinoma. Lastly, a 54 year old male who underwent Radical mastoidectomy with histopathology reports of a moderately differentiated squamous cell carcinoma. Conclusion: Standard treatment modality is still unclear because of the rarity of this condition. However, surgical resection with negative margins followed by concurrent chemotherapy and radiation is the most commonly performed approach1. For the above-mentioned patients, concurrent chemotherapy and radiation therapy was given which showed significant treatment response.
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