Antimicrobial Activity of Secondary Metabolites from Endophytic Fungus Fusarium sp. Isolated from Eichhornia crassipes Linn.

The active metabolites producing endophytic fungus, Fusarium sp., was isolated from Eichhornia crassipes Linn. yielded four compounds: “altersolanol (1)”, “4-hydroxydihydronorjavanicin (2)”, “5-hydroxy-7-methoxy-2-isopropylchromone (3)” and “fusaraichromenone (4)”. Structures of 1-4 were elucidated by analysis of their spectroscopic data. The antimicrobial activity was tested by using four bacteria; methicillin-resistant Staphylococcus aureus (MRSA SK1), Staphylococcus aureus (SA), Escherichia coli (EC) and Pseudomonas aeruginosa ATCC27853 (PA)and two yeast; Cryptococcus neoformans ATCC90112 flucytosine – resistant (CN90112) and Candida albicans ATCC 90028 (CA90028) to adverse effect showed that compound 1 and 3 had moderate antibacterial activity against MRSA, SA, PA and SK1 with same MIC value 16 μg/mL. However, all pure compounds showed relatively low activities to inhibit the growth of CA90028 and CN91112 yeast.