摘要:TREG细胞的流行及其对口腔癌细胞生长的抑制作用

Regulating T-cells and Their Response to Cancer Pub Date : 2019-02-01 DOI:10.1158/2326-6074.CRICIMTEATIAACR18-A167

S. Aggarwal, Suresh C. Sharma, Satya N. Das

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引用次数: 0

摘要

口腔鳞状细胞癌是影响亚洲国家的主要癌症之一。主要的致病因素是吸烟习惯。据报道，这些患者的免疫功能障碍是影响肿瘤生长和传播的主要因素之一，影响患者的无病生存。我们通过多色流式细胞术评估了OSCC患者中调节性T (Treg) CD4+CD25+FoxP3+亚群的表型和功能特征。随后，我们在体外研究了TDG对OSCC细胞株生长的抑制作用。引文格式:Sadhna Aggarwal, Suresh C. Sharma, Satya N. Das。TREG细胞的流行及其对口腔癌细胞生长的抑制作用[摘要]。第四届CRI-CIMT-EATI-AACR国际癌症免疫治疗会议:将科学转化为生存;2018年9月30日至10月3日;纽约，纽约。费城(PA): AACR;癌症免疫学杂志，2019;7(2增刊):摘要nr A167。

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Abstract A167: Prevalence of TREG cells and effects of their inhibition on growth of oral cancer cells

Oral squamous cell carcinoma (OSCC) is one of the major cancers affecting Asian countries. The main causative factor has been tobacco habit. It has been reported that immune dysfunction in these patients is one of the major factors for tumor growth and dissemination that affects disease-free survival of the patients. We assessed the phenotypic and functional characteristics of regulatory T (Treg) CD4+CD25+FoxP3+subsets in patients with OSCC by multicoloured flow cytometry. Subsequently we investigated the effects their inhibition via TDG on growth of OSCC cell lines in vitro. An increased (p Citation Format: Sadhna Aggarwal, Suresh C. Sharma, Satya N. Das. Prevalence of TREG cells and effects of their inhibition on growth of oral cancer cells [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A167.

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Regulating T-cells and Their Response to Cancer

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