IT Solutions for Preventing and Monitoring Adverse Drug Reactions: A Systematic Literature Review

∗ Patient safety is one of the most crucial aspects in the healthcare industry. Minimizing adverse drug reactions (ADR) and medical errors are the focus for improving patient’s quality of life. However, it is undeniable that no drug is free from side effects. In fact, ADR caused 2.3% to 21.2% of hospital admissions, and ADR cases are also hard to trace because less than 5% of cases were reported directly by the patient. An increasing amount of research has been conducted to see the potential of information technology (IT) for preventing and monitoring ADR. However, we rarely find a comprehensive article review to discuss IT solutions for preventing and monitoring ADR. Therefore, this paper conducted a systematic review of papers published in 2016-2021 to see the current IT solutions for preventing and monitoring ADR. This paper focuses on clinical decision support system (CDSS) as the solutions for preventing ADR, and Patient Health Monitoring (PHM) software for monitoring ADR. Our study found most previous research conducted by developed countries with cardiology and endocrinology as the most prevalent disease domain. In relation to prior research on CDSS, the use of knowledge-based CDSS still dominates the previous research. At the same time, mobile is the most used platform for monitoring ADR. We also attempted to categorize the features based on the approaches to give drug recommendations and report ADR.