妊娠期子痫前期指标与母体细胞因子的相关性研究

A. Markova, M. Hadži-Lega, G. Dimitrov, Gligor Tofovski, J. Georgievska, E. Dzikova, I. Kjaev
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引用次数: 0

摘要

目的:实际研究的目的是评价妊娠晚期抗炎IL-10细胞因子的形成与中重度子痫前期几个指标的关系。材料和方法:在妊娠晚期,对马其顿共和国斯科普里妇产科大学住院的100名伴有不同程度先兆子痫的妊娠妇女和100名血压正常的患者进行了子痫前期生化标志物(PE)和母体IL-10水平的检测。根据子痫前期的严重程度将子痫前期患者分为中度和重度子痫前期组。对不同参数进行Logistic回归分析,确定重度子痫前期发生的预测值。结果:回归分析发现收缩压160 mmHg及以上、舒张压100 mmHg及以上、妊娠期持续性蛋白尿、血清LDH浓度450 U/L及以上、血清IL-10浓度降低是严重子痫前期的重要预测因素。结论:重度子痫前期孕妇血清IL-10浓度明显低于中度子痫前期孕妇血清IL-10浓度,可视为重度子痫前期的主要病理特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Indicators of Preeclampsia in Correlation with Maternal Cytokines in Pregnancy
Aim: the purpose of the actual study was to evaluate, in the third trimester of pregnancy, the relationship between the formation of anti-inflammatory IL-10 cytokine and several indicators of moderate and severe preeclampsia. Materials and methods: in the third trimester of gesta- tion, examination of the biochemical markers of preeclampsia (PE) and maternal IL-10 levels was conducted in 100 women with pregnancies complicated by varying degrees of preeclamp - sia and in 100 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with preeclampsia were categorized into moderate and severe preeclampsia groups according to the degree of preeclampsia. Logistic regression of the different parameters for the occurrence of severe preeclampsia analysis was used to determine the predictive value. Results: the regression analysis detected systolic blood pressure of 160 mmHg or higher, diastolic blood pressure of 100 mmHg or higher, persistent proteinuria in pregnancy, serum LDH concentration of 450 U/L or higher, and reduced serum concentrations of IL-10 as significant predictors of severe preeclampsia. Conclusion: signifi - cantly, lower IL-10 concentrations in maternal serum in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe form of preeclampsia.
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