深部肿瘤治疗过程中组织温度自动控制的有限元数值研究

Mridul Sannyal, A. Mukaddes
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摘要

医生们使用了几种治疗人体组织中不健康细胞的方法。将热量传递到受感染的细胞是移除该细胞的方法之一。点加热是一种将热量传递到感染细胞的有效技术。但在这种技术中,有可能破坏感染细胞附近的健康组织。仅仅控制涂抹器的温度并不能使不健康的组织免受伤害。本文开发了生物热方程的二维有限程序,用于测量点加热处理过程中的温度。Pennes生物热方程是本研究中考虑的瞬态传热分析的主要数学模型。考虑了三个点加热技术的情况下,研究温度分布的组织使用开发的代码。它们是恒定点加热,步进点加热和温度控制点加热。组织温度控制点加热旨在将健康组织温度限制在损伤阈值温度以下。利用温度曲线,利用Arrhenius速率方程测量组织损伤率。在这三种技术中,组织温控点加热是一种较好的技术。本研究结果对临床医师及生物医学工程人员有一定的参考价值。医生们使用了几种治疗人体组织中不健康细胞的方法。将热量传递到受感染的细胞是移除该细胞的方法之一。点加热是一种将热量传递到感染细胞的有效技术。但在这种技术中,有可能破坏感染细胞附近的健康组织。仅仅控制涂抹器的温度并不能使不健康的组织免受伤害。本文开发了生物热方程的二维有限程序,用于测量点加热处理过程中的温度。Pennes生物热方程是本研究中考虑的瞬态传热分析的主要数学模型。考虑了三个点加热技术的情况下,研究温度分布的组织使用开发的代码。它们是恒定点加热,步进点加热和温度控制点加热。组织温度控制点加热是为了休息而设计的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Automatic controlling the tissue temperature during treatment of deep tumor: A numerical study using finite element method
Several methods of treating unhealthy cell in human tissue are used by the physicians. Transferring the heat to the infected cell is one of the methods to remove that cell. Point heating is an available technique to transfer heat to the infected cell. But in this technique, there is a possibility to damage the healthy tissue nearby the infected cell. Only controlling the temperature of the applicator cannot save the unhealthy tissue from damage. In this paper, the two dimensional finite code for bio-heat equation has been developed to measure the temperature during the treatment of point heating. Pennes bio heat equation is the main mathematical model for the transient heat transfer analysis considered in this research. Three cases of point heating techniques are considered to study the temperature profile of the tissue using the developed code. Those are constant point heating, step point heating and temperature controlled point heating. The tissue temperature controlled point heating is designed to restrict the healthy tissue temperature below the damage threshold temperature. Using the temperature profile, tissue damage rate is measured with the help of Arrhenius rate equation. Among these three techniques tissue temperature controlled point heating is shown as better one. The outcome of this research will be helpful for the physicians as well as bio-medical engineer.Several methods of treating unhealthy cell in human tissue are used by the physicians. Transferring the heat to the infected cell is one of the methods to remove that cell. Point heating is an available technique to transfer heat to the infected cell. But in this technique, there is a possibility to damage the healthy tissue nearby the infected cell. Only controlling the temperature of the applicator cannot save the unhealthy tissue from damage. In this paper, the two dimensional finite code for bio-heat equation has been developed to measure the temperature during the treatment of point heating. Pennes bio heat equation is the main mathematical model for the transient heat transfer analysis considered in this research. Three cases of point heating techniques are considered to study the temperature profile of the tissue using the developed code. Those are constant point heating, step point heating and temperature controlled point heating. The tissue temperature controlled point heating is designed to rest...
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