南印度肺结核和HLA的关系

Tubercle Pub Date : 1991-06-01 DOI:10.1016/0041-3879(91)90039-U

V. Brahmajothi , R.M. Pitchappan , V.N. Kakkanaiah , M. Sashidhar , K. Rajaram , S. Ramu , K. Palanimurugan , C.N. Paramasivan , R. Prabhakar

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引用次数: 168

摘要

204例涂阳肺结核患者中HLA-A10、138和DR2较404例对照高(p=0.01);最大归因风险(0.29)与HLA-DR2相关。疾病的放射学程度也与HLA-DR2相关(p = 0.0001)。在152例涂片阴性肺结核患者中，对照组HLA-A10和B8的频率高于对照组(p = 0.001和0.01)，而DR2的频率低于对照组(p = 0.001和0.01)。HLA-DR2可能参与晚期肺结核的发病机制。对内婚制的、遗传差异的人群(种姓)的研究揭示了他们特有的其他HLA关联(A3、B12和DR4)，表明与HLA复合物相关的基因也可能在结核病的发病机制中起重要作用。

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Association of pulmonary tuberculosis and HLA in South India

In 204 patients with smear-positive pulmonary tuberculosis HLA-A10, 138 and DR2 were more frequently found than in 404 control subjects (p=0.01); the greatest attributable risk (0.29) was associated with HLA-DR2. The radiographic extent of disease was also associated with HLA-DR2 (p = 0.0001). In 152 patients with smear-negative pulmonary tuberculosis, the frequencies of HLA-A10 and B8, but not DR2, were greater in the control subjects (p = 0.001 and 0.01 respectively). HLA-DR2 may be involved in the pathogenesis of advanced pulmonary tuberculosis. Study of endogamous, genetically disparate populations (caste) revealed other HLA associations (A3, B12 and DR4) unique to them, suggesting that genes linked with the HLA complex might also be significant in the pathogenesis of tuberculosis.

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Tubercle

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