Relationship between the triglyceride glucose index and collateral index in patients with coronary chronic total occlusion

Objectives: This study aims to investigate the relationship between the triglyceride glucose (TyG) index and coronary collateral circulation (CCC) in patients with coronary chronic total occlusion (CTO). Patients and methods: Between July 2018 and December 2019, a total of 228 consecutive patients (186 males, 42 females; mean age: 62.2±9.7 years; range, 18 to 80 years) with stable or unstable angina pectoris who had CCO in at least one coronary artery were retrospectively analyzed. The TyG index was calculated. Coronary collateral circulation was evaluated using the Rentrop grading system. The patients were divided into two groups as low-grade CCC (Group 1, n=101) and high-grade CCC (Group 2, n=127). Results: There was no significant difference in the body mass index, left ventricular ejection fraction, height, weight, the frequency of dyslipidemia, hypertension, diabetes mellitus, and smoking between the groups (p>0.01). In the multivariate logistic regression analysis, high TyG index (odds ratio [OR]: 1.345; 95% confidence interval [CI]: 1.120-2.184; p<0.001) and uric acid levels (OR: 0.249; 95% CI: 0.105-0.491; p=0.013) were the independent predictors of poor CCC. Conclusion: Our study results suggest that a high TyG index is related to poor collateral circulation.